GPCRdb

desloratadine

Agent/drug
Bioactivity

desloratadine

SMILES	Clc1ccc2c(c1)CCc1cccnc1C2=C1CCNCC1
InChIKey	JAUOIFJMECXRGI-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	1
Rotatable bonds	0
Molecular weight (Da)	310.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Structure pdb	8X64

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	5.70	5.70	5.70	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.24	8.24	8.24	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.01	6.01	6.01	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.22	8.22	8.22	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.03	8.03	8.03	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.10	8.10	8.10	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	7.55	7.55	7.55	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.12	8.12	8.12	Drug Central
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	7.80	7.80	7.80	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.11	8.11	8.11	Drug Central
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	6.00	6.00	6.00	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	8.22	8.22	8.22	Drug Central
D₃	DRD3	Human	Dopamine	A	pKi	6.19	6.19	6.19	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	8.21	8.21	8.21	Drug Central
H₁	HRH1	Human	Histamine	A	pKi	9.01	9.01	9.01	Guide to Pharmacology
H₁	HRH1	Human	Histamine	A	pKi	8.80	8.92	9.01	ChEMBL
H₁	HRH1	Human	Histamine	A	pKd	7.62	7.62	7.62	ChEMBL
H₁	HRH1	Human	Histamine	A	pKi	8.03	8.03	8.03	Drug Central
H₂	HRH2	Human	Histamine	A	pKi	5.97	5.97	5.97	ChEMBL
H₂	HRH2	Human	Histamine	A	pKi	8.22	8.22	8.22	Drug Central

Showing 1 to 20 of 31 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	5.44	5.44	5.44	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	5.67	5.67	5.67	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	7.48	7.48	7.48	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	7.37	7.37	7.37	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	7.52	7.52	7.52	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pIC50	5.66	5.66	5.66	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	5.72	5.72	5.72	ChEMBL
H₁	HRH1	Human	Histamine	A	pIC50	4.80	6.58	8.73	ChEMBL
H₂	HRH2	Human	Histamine	A	pIC50	5.96	5.96	5.96	ChEMBL
H₄	HRH4	Human	Histamine	A	pIC50	8.32	8.32	8.32	Drug Central
H₄	HRH4	Human	Histamine	A	pIC50	4.80	4.80	4.80	ChEMBL
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pIC50	6.57	6.57	6.57	ChEMBL
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pIC50	6.97	6.97	6.97	ChEMBL
M₃	ACM3	Human	Acetylcholine (muscarinic)	A	pIC50	6.35	6.35	6.35	ChEMBL
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pIC50	6.47	6.47	6.47	ChEMBL
M₅	ACM5	Human	Acetylcholine (muscarinic)	A	pIC50	6.54	6.54	6.54	ChEMBL

Showing 1 to 16 of 16 entries

desloratadine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 5

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Structure pdb	8X64

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Acute nasopharyngitis	CA00	R06A	0.605	3	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic or hypersensitivity conditions of unspecified type	4A8Z	R06A	0.494	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic rhinitis due to other seasonal allergens	CA08.01	R06A	0.610	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic rhinitis, unspecified	CA08.0Z	R06A	0.616	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Atopic eczema, unspecified	EA80.Z	R06A	0.474	3	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Dermatitis or eczema, unspecified	EA8Z	R06A	0.375	3	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Other allergic rhinitis	CA08.03	R06A	0.602	3	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Pruritus, unspecified	EC90.Z	R06A	0.602	3	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Urticaria of unspecified type	EB05	R06A	0.606	4	Yes

Showing 1 to 9 of 9 entries