CHEMBL379602


SMILES COc1ccccc1N1CCN(Cc2cnn(-c3ccccc3)c2)CC1
InChIKey VFDZFYCKUWKAKM-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 0
Rotatable bonds 5
Molecular weight (Da) 348.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2A 5HT2A Pig 5-Hydroxytryptamine A pKi 5.89 5.89 5.89 ChEMBL
D1 DRD1 Pig Dopamine A pKi 6.0 6.0 6.0 ChEMBL
D4 DRD4 Human Dopamine A pKi 9.55 9.55 9.55 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.17 8.17 8.17 ChEMBL
D3 DRD3 Human Dopamine A pKi 7.46 7.46 7.46 ChEMBL
D2 DRD2 Human Dopamine A pKi 7.96 8.03 8.1 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D4 DRD4 Human Dopamine A pEC50 9.22 9.22 9.22 ChEMBL
D3 DRD3 Human Dopamine A pEC50 9.68 9.68 9.68 ChEMBL
D2 DRD2 Human Dopamine A pEC50 9.55 9.61 9.66 ChEMBL