GPCRdb

dextromethorphan

Agent/drug
Bioactivity

dextromethorphan

SMILES	COc1ccc2c(c1)[C@]13CCCC[C@@H]1[C@H](C2)N(C)CC3
InChIKey	MKXZASYAUGDDCJ-NJAFHUGGSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	0
Rotatable bonds	1
Molecular weight (Da)	271.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

δ	OPRD	Rat	Opioid	A	pKi	5.00	5.00	5.00	PDSP Ki database
κ	OPRK	Rat	Opioid	A	pKi	5.15	5.15	5.15	PDSP Ki database
μ	OPRM	Rat	Opioid	A	pKi	5.89	5.89	5.89	PDSP Ki database

Showing 1 to 3 of 3 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	4.75	5.08	5.40	ChEMBL
TAS2R46	T2R46	Human	Taste 2	T2	pEC50	8.35	8.35	8.35	Drug Central
TAS2R46	T2R46	Human	Taste 2	T2	pEC50	4.51	4.51	4.51	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	8.20	8.20	8.20	ChEMBL

Showing 1 to 4 of 4 entries

dextromethorphan

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved No

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central GPCRdb

Compound is not listed as a drug.