5-MeOT


SMILES NCCc1c[nH]c2c1cc(OC)cc2
InChIKey JTEJPPKMYBDEMY-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 3
Molecular weight (Da) 190.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations 5-HT2C 5-HT6

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 7.4 8.05 8.7 Guide to Pharmacology
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 5.5 5.85 6.2 Guide to Pharmacology
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 5.9 5.9 5.9 Guide to Pharmacology
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.9 8.9 8.9 Guide to Pharmacology
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.7 7.25 7.8 Guide to Pharmacology
5-HT4 5HT4R Human 5-Hydroxytryptamine A pKi 5.6 6.2 6.8 Guide to Pharmacology
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 8.3 8.9 9.5 Guide to Pharmacology
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 6.9 7.65 8.4 Guide to Pharmacology
5-HT4 5HT4R Rat 5-Hydroxytryptamine A pKi 6.3 6.85 7.4 Guide to Pharmacology
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 6.3 6.3 6.3 Guide to Pharmacology
5-HT4 5HT4R Mouse 5-Hydroxytryptamine A pKi 6.6 6.6 6.6 Guide to Pharmacology
5-HT7 5HT7R Mouse 5-Hydroxytryptamine A pKi 8.2 8.2 8.2 Guide to Pharmacology
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 8.8 9.0 9.2 Guide to Pharmacology
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 9.03 9.03 9.03 ChEMBL
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 6.3 6.3 6.3 ChEMBL
5-HT4 5HT4R Human 5-Hydroxytryptamine A pKi 6.61 7.09 7.57 ChEMBL
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 6.4 7.35 8.4 ChEMBL
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 8.46 8.46 8.46 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 8.27 8.33 8.39 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 8.3 8.5 8.7 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 7.97 8.26 8.49 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 7.06 7.06 7.06 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.35 7.35 7.35 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.52 7.42 8.32 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 7.47 8.32 8.77 PDSP Ki database
5-HT1D 5HT1D Rat 5-Hydroxytryptamine A pKi 7.14 7.88 8.62 PDSP Ki database
5-HT1D F1MMU1 Bovine 5-Hydroxytryptamine A pKi 8.4 8.43 8.6 PDSP Ki database
5-HT2C K7GSR7 Pig 5-Hydroxytryptamine A pKi 7.36 7.62 8.1 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.14 6.83 7.42 PDSP Ki database
5-HT2A 5HT2A Pig 5-Hydroxytryptamine A pKi 7.3 7.3 7.3 PDSP Ki database
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 6.89 7.59 8.43 PDSP Ki database
5-HT4 5HT4R Rat 5-Hydroxytryptamine A pKi 6.3 6.64 7.4 PDSP Ki database
5-HT4 5HT4R Mouse 5-Hydroxytryptamine A pKi 6.28 6.37 6.64 PDSP Ki database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 7.42 8.15 9.12 PDSP Ki database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 8.75 9.03 9.24 PDSP Ki database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 7.16 7.42 7.74 PDSP Ki database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 6.4 7.33 8.77 PDSP Ki database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 6.67 7.25 7.85 PDSP Ki database
5-HT4 5HT4R Human 5-Hydroxytryptamine A pKi 6.0 6.35 6.81 PDSP Ki database
5-HT4 5HT4R Guinea pig 5-Hydroxytryptamine A pKi 6.2 6.42 6.6 PDSP Ki database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 7.79 8.54 9.29 PDSP Ki database
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.28 7.28 7.28 PDSP Ki database
5-HT2B 5HT2B Rat 5-Hydroxytryptamine A pKi 8.04 8.08 8.15 PDSP Ki database
5-HT7 5HT7R Guinea pig 5-Hydroxytryptamine A pKi 8.8 9.17 9.6 PDSP Ki database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 8.3 8.54 9.03 PDSP Ki database
5-HT6 5HT6R Mouse 5-Hydroxytryptamine A pKi 7.63 8.04 8.3 PDSP Ki database
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 5.5 5.5 5.5 PDSP Ki database
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 5.93 5.93 5.93 PDSP Ki database
MT1 MTR1A Human Melatonin A pKi 5.0 5.0 5.0 PDSP Ki database
MT2 MTR1B Human Melatonin A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT1D 5HT1D Dog 5-Hydroxytryptamine A pKi 7.51 7.85 8.2 PDSP Ki database
5-HT7 5HT7R Mouse 5-Hydroxytryptamine A pKi 8.2 8.2 8.2 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.49 8.49 8.49 ChEMBL
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 7.3 7.4 7.5 Guide to Pharmacology
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 7.4 7.4 7.4 Guide to Pharmacology
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 6.64 7.5 8.6 PDSP Ki database
5-HT2B 5HT2B Rat 5-Hydroxytryptamine A pKi 8.0 8.0 8.0 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pEC50 9.3 9.3 9.3 ChEMBL
NPS NPSR1 Human Neuropeptide S A Potency 5.5 5.5 5.5 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 4.4 4.4 4.4 ChEMBL