ADX-47273
| SMILES | Fc1ccc(cc1)C(=O)N1CCC[C@@H](C1)c1onc(n1)c1ccc(cc1)F |
| InChIKey | VXQCCZHCFBHTTD-HNNXBMFYSA-N |
Chemical properties
| Hydrogen bond acceptors | 4 |
| Hydrogen bond donors | 0 |
| Rotatable bonds | 3 |
| Molecular weight (Da) | 369.1 |
Drug properties
| Molecular type | Small molecule |
| Endogenous/Surrogate | Surrogate |
| Approved drug | No |
Database connections
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| CRF1 | CRFR1 | Human | Corticotropin-releasing factor | B1 | pKi | 8.3 | 8.65 | 9.0 | Guide to Pharmacology |
| CRF1 | CRFR1 | Human | Corticotropin-releasing factor | B1 | pKi | 8.7 | 8.74 | 8.77 | ChEMBL |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| CRF1 | CRFR1 | Human | Corticotropin-releasing factor | B1 | pIC50 | 7.09 | 7.32 | 7.4 | ChEMBL |
| CRF1 | CRFR1 | Rat | Corticotropin-releasing factor | B1 | pIC50 | 8.38 | 8.74 | 8.92 | ChEMBL |