bufotenine


SMILES CN(CCc1c[nH]c2c1cc(O)cc2)C
InChIKey VTTONGPRPXSUTJ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 3
Molecular weight (Da) 204.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Ligand site mutations 5-HT2A 5-HT2C

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 7.7 7.85 8.0 Guide to Pharmacology
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.8 6.8 6.8 Guide to Pharmacology
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 7.0 7.7 8.4 Guide to Pharmacology
5-HT7 5HT7R Mouse 5-Hydroxytryptamine A pKi 7.0 7.0 7.0 Guide to Pharmacology
5-HT5A 5HT5A Mouse 5-Hydroxytryptamine A pKi 5.3 5.65 6.0 Guide to Pharmacology
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 8.1 8.1 8.1 ChEMBL
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 6.04 6.04 6.04 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 6.59 7.09 7.6 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.16 7.16 7.16 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKd 8.5 8.5 8.5 ChEMBL
5-HT1A F6Q2H9 Bovine 5-Hydroxytryptamine A pKi 8.6 8.6 8.6 PDSP Ki database
5-HT1A A0A4X1UTF5 Pig 5-Hydroxytryptamine A pKi 7.6 7.6 7.6 PDSP Ki database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 5.0 6.29 6.92 PDSP Ki database
5-HT2A 5HT2A Bovine 5-Hydroxytryptamine A pKi 6.48 6.48 6.48 PDSP Ki database
5-HT1D F1MMU1 Bovine 5-Hydroxytryptamine A pKi 7.69 8.1 8.43 PDSP Ki database
5-HT2C K7GSR7 Pig 5-Hydroxytryptamine A pKi 7.15 7.16 7.2 PDSP Ki database
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 6.95 7.65 8.35 PDSP Ki database
5-HT5A 5HT5A Mouse 5-Hydroxytryptamine A pKi 5.54 5.85 6.0 PDSP Ki database
5-HT7 5HT7R Guinea pig 5-Hydroxytryptamine A pKi 7.02 7.46 7.7 PDSP Ki database
5-HT6 5HT6R Mouse 5-Hydroxytryptamine A pKi 7.0 7.0 7.0 PDSP Ki database
5-HT1F 5HT1F Mouse 5-Hydroxytryptamine A pKi 7.5 7.5 7.5 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.84 7.33 7.82 PDSP Ki database
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 5.99 7.75 8.48 PDSP Ki database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 6.04 6.35 7.28 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database