CHEMBL3804846


SMILES O=C1N[C@H](c2cncc(C#Cc3ccccc3)c2)[C@@H](c2cc(F)ccc2F)O1
InChIKey HIRXVQATYCZQHB-NHCUHLMSSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 2
Molecular weight (Da) 376.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Human Metabotropic glutamate C pKi 8.8 8.8 8.8 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu5 GRM5 Rat Metabotropic glutamate C pIC50 8.7 8.7 8.7 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pEC50 8.59 8.59 8.59 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pIC50 8.52 8.52 8.52 ChEMBL