bremelanotide [1486]



bremelanotide

No image available
SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](C(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O
InChIKey FFHBJDQSGDNCIV-MFVUMRCOSA-N
Sequence None
HELM PEPTIDE1{H.[dF].R.W.K}|PEPTIDE2{[ac].[Nle].D}$PEPTIDE2,PEPTIDE1,3:R2-1:R1|PEPTIDE2,PEPTIDE1,3:R3-5:R3$$$

Chemical Properties

Hydrogen bond acceptors 11
Hydrogen bond donors 13
Rotatable bonds 17
Log P -0.649
Molecular weight (Da) 1024.5
Stereochemistry info unspecified

Database connections

Structure pdb 7F55
Model (Boltz2) MC3 MC4 MC2 MC5 MC1

Bioactivities

Receptor Activity Source
Protein Gene Species Family Class Type Min Avg Max Database
Receptor Activity Source
Protein Gene Species Family Class Type Min Avg Max Database

bremelanotide

No image available

Drug properties

Molecular type Peptide
Physiological/Surrogate Surrogate
Approved drug Yes

Distribution across phases (no. indications)

Phase I 5
Phase II 0
Phase III 0
Phase IV 5

Database connections

Structure pdb 7F55
Model (Boltz2) MC3 MC4 MC2 MC5 MC1

Sankey plot

Drug Information

Target Disease
Gene Protein Receptor family Ligand type Class Name Phase ICD11 ATC Association score