Ligand Data

Ligand

id 1513
Name fasiglifam
SMILES OC(=O)C[C@@H]1COc2c1ccc(c2)OCc1cccc(c1)c1c(C)cc(cc1C)OCCCS(=O)(=O)C
InChIKey BZCALJIHZVNMGJ-HSZRJFAPSA-N
Type small-molecule
External Links
Structure pdb 4PHU

Structure

Properties

Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 11
Molecular weight 524.2


Bioactivity

Receptor Affinity (nM) Potency (nM)
GTP Uniprot Species Family Class Min Avg Max Min Avg Max
FFA1 FFAR1 Mouse Free fatty acid A (Rhodopsin) 8.6 8.6 8.6
FFA1 FFAR1 Rat Free fatty acid A (Rhodopsin) 140 140 140 36.0 6792.0 27000.0
FFA1 FFAR1 Human Free fatty acid A (Rhodopsin) 4.5 21.5 38.0 0.3 204.8 5100.0