neurotensin


SMILES None
InChIKey PCJGZPGTCUMMOT-ISULXFBGSA-N
Sequence XLYENKPRRPYIL

Chemical properties

Hydrogen bond acceptors None
Hydrogen bond donors None
Rotatable bonds None
Molecular weight (Da)

Drug properties

Molecular type Peptide
Physiological/Surrogate Endogenous
Approved drug No

Database connections

Structure pdb 4BUO 3ZEV 4BV0 4BWB 4XES 4XEE 7L0Q 7L0P 5T04 7L0R 7L0S 8FMZ 8FN0 8FN1

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NTS1 NTR1 Human Neurotensin A pKi 8.3 9.0 9.7 Guide to Pharmacology
NTS2 NTR2 Human Neurotensin A pKi 8.8 8.8 8.8 Guide to Pharmacology
NTS2 NTR2 Mouse Neurotensin A pKd 8.6 8.6 8.6 Guide to Pharmacology
NTS1 NTR1 Rat Neurotensin A pKi 8.2 9.1 10.0 Guide to Pharmacology
NTS1 NTR1 Rat Neurotensin A pKd 9.6 9.75 9.9 Guide to Pharmacology
NTS1 NTR1 Mouse Neurotensin A pKi 9.77 9.77 9.77 ChEMBL
NTS2 NTR2 Rat Neurotensin A pKi 7.55 7.65 7.72 ChEMBL
NTS1 NTR1 Rat Neurotensin A pKi 8.77 8.87 8.96 ChEMBL
NTS2 NTR2 Human Neurotensin A pKi 8.31 8.34 8.39 ChEMBL
NTS1 NTR1 Human Neurotensin A pKi 8.48 8.88 9.57 ChEMBL
NTS1 NTR1 Human Neurotensin A pKd 9.23 9.26 9.29 ChEMBL
NTS2 NTR2 Mouse Neurotensin A pKi 8.15 8.15 8.15 PDSP Ki database
NTS1 NTR1 Mouse Neurotensin A pKi 9.6 9.6 9.6 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NTS2 NTR2 Mouse Neurotensin A pIC50 8.5 8.6 8.7 Guide to Pharmacology
NTS2 NTR2 Rat Neurotensin A pIC50 8.649999999999999 8.65 8.65 Guide to Pharmacology
NTS1 NTR1 Mouse Neurotensin A pEC50 8.7 8.7 8.7 ChEMBL
NTS2 NTR2 Rat Neurotensin A pIC50 6.94 7.35 7.73 ChEMBL
NTS1 NTR1 Rat Neurotensin A pEC50 10.4 10.4 10.4 ChEMBL
NTS2 NTR2 Human Neurotensin A pIC50 8.96 8.96 8.96 ChEMBL
NTS2 NTR2 Human Neurotensin A pEC50 6.96 6.96 6.96 ChEMBL
NTS1 NTR1 Human Neurotensin A pIC50 8.22 9.19 9.8 ChEMBL
NTS1 NTR1 Human Neurotensin A pEC50 6.51 8.47 9.64 ChEMBL