evatanepag


SMILES OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C
InChIKey WOHRHWDYFNWPNG-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 9
Molecular weight (Da) 468.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
EP4 PE2R4 Human Prostanoid A pKi 8.6 8.6 8.6 Guide to Pharmacology
EP2 PE2R2 Human Prostanoid A pKi 7.3 7.55 7.8 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
EP2 PE2R2 Rat Prostanoid A pIC50 7.3 7.3 7.3 Guide to Pharmacology
EP2 PE2R2 Rat Prostanoid A pEC50 9.5 9.5 9.5 Guide to Pharmacology
EP2 PE2R2 Rat Prostanoid A pEC50 9.52 9.52 9.52 ChEMBL
EP2 PE2R2 Rat Prostanoid A pIC50 7.3 7.3 7.3 ChEMBL
EP2 PE2R2 Human Prostanoid A pEC50 7.77 8.04 8.3 ChEMBL