ISOCLOZAPINE
SMILES | CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1 |
InChIKey | APOMSSAGEAOUGO-UHFFFAOYSA-N |
Chemical properties
Hydrogen bond acceptors | 4 |
Hydrogen bond donors | 1 |
Rotatable bonds | 0 |
Molecular weight (Da) | 326.1 |
Drug properties
Molecular type | Small molecule |
Endogenous/Surrogate | Surrogate |
Approved drug | No |
Database connections
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
5-HT2C | 5HT2C | Rat | 5-Hydroxytryptamine | A | pKi | 7.96 | 7.96 | 7.96 | ChEMBL |
D1 | DRD1 | Rat | Dopamine | A | pKi | 7.55 | 7.65 | 7.85 | ChEMBL |
D2 | DRD2 | Rat | Dopamine | A | pKi | 7.33 | 7.71 | 7.9 | ChEMBL |
D4 | DRD4 | Human | Dopamine | A | pKi | 7.8 | 7.8 | 7.8 | ChEMBL |
D2 | DRD2 | Human | Dopamine | A | pKi | 7.33 | 7.33 | 7.33 | ChEMBL |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
5-HT2C | 5HT2C | Rat | 5-Hydroxytryptamine | A | pIC50 | 8.54 | 8.54 | 8.54 | ChEMBL |
D1 | DRD1 | Rat | Dopamine | A | pIC50 | 7.2 | 7.58 | 7.96 | ChEMBL |
D2 | DRD2 | Rat | Dopamine | A | pIC50 | 6.66 | 7.28 | 7.89 | ChEMBL |
D4 | DRD4 | Human | Dopamine | A | pIC50 | 6.96 | 6.96 | 6.96 | ChEMBL |
M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pIC50 | 8.22 | 8.22 | 8.22 | ChEMBL |
D3 | DRD3 | Human | Dopamine | A | pIC50 | 6.92 | 6.92 | 6.92 | ChEMBL |
D2 | DRD2 | Human | Dopamine | A | pIC50 | 7.47 | 7.47 | 7.47 | ChEMBL |