normorphine
SMILES | O[C@H]1C=C[C@@H]2[C@@]34[C@H]1Oc1c4c(C[C@H]2NCC3)ccc1O |
InChIKey | ONBWJWYUHXVEJS-ZTYRTETDSA-N |
Chemical properties
Hydrogen bond acceptors | 4 |
Hydrogen bond donors | 3 |
Rotatable bonds | 0 |
Molecular weight (Da) | 271.1 |
Drug properties
Molecular type | Small molecule |
Endogenous/Surrogate | Surrogate |
Approved drug | No |
Database connections
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
D2 | DRD2 | Human | Dopamine | A | pKi | 7.87 | 7.87 | 7.87 | Guide to Pharmacology |
D3 | DRD3 | Human | Dopamine | A | pKi | 7.74 | 7.74 | 7.74 | Guide to Pharmacology |
D5 | DRD5 | Human | Dopamine | A | pKi | 8.1 | 8.1 | 8.1 | Guide to Pharmacology |
D1 | DRD1 | Rat | Dopamine | A | pKi | 7.42 | 7.42 | 7.42 | ChEMBL |
5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 7.06 | 7.06 | 7.06 | PDSP Ki database |
D1 | DRD1 | Human | Dopamine | A | pKi | 8.4 | 8.46 | 8.52 | PDSP Ki database |
D3 | DRD3 | Human | Dopamine | A | pKi | 6.52 | 8.15 | 9.52 | PDSP Ki database |
5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 5.1 | 5.1 | 5.1 | PDSP Ki database |
5-HT2C | 5HT2C | Rat | 5-Hydroxytryptamine | A | pKi | 6.53 | 6.84 | 6.99 | PDSP Ki database |
D2 | DRD2 | Human | Dopamine | A | pKi | 6.33 | 8.44 | 9.85 | PDSP Ki database |
D1 | DRD1 | Rat | Dopamine | A | pKi | 6.04 | 7.55 | 9.49 | PDSP Ki database |
D2 | DRD2 | Rat | Dopamine | A | pKi | 6.66 | 8.04 | 9.47 | PDSP Ki database |
D2 | DRD2 | Bovine | Dopamine | A | pKi | 7.32 | 8.43 | 9.01 | PDSP Ki database |
D1 | DRD1 | Bovine | Dopamine | A | pKi | 5.1 | 6.64 | 8.5 | PDSP Ki database |
D5 | DRD5 | Human | Dopamine | A | pKi | 8.1 | 8.1 | 8.1 | PDSP Ki database |
D2 | DRD2 | Mouse | Dopamine | A | pKi | 7.0 | 8.6 | 9.47 | PDSP Ki database |
D4 | DRD4 | Human | Dopamine | A | pKi | 6.0 | 7.23 | 8.8 | PDSP Ki database |
D1 | DRD1 | Mouse | Dopamine | A | pKi | 6.32 | 7.91 | 9.49 | PDSP Ki database |
H1 | HRH1 | Human | Histamine | A | pKi | 8.24 | 8.66 | 9.07 | PDSP Ki database |
5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 8.29 | 8.29 | 8.29 | Drug Central |
5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 8.15 | 8.15 | 8.15 | Drug Central |
D1 | DRD1 | Human | Dopamine | A | pKi | 8.08 | 8.08 | 8.08 | Drug Central |
D2 | DRD2 | Human | Dopamine | A | pKi | 8.05 | 8.05 | 8.05 | Drug Central |
D3 | DRD3 | Human | Dopamine | A | pKi | 8.05 | 8.05 | 8.05 | Drug Central |
D4 | DRD4 | Human | Dopamine | A | pKi | 8.06 | 8.06 | 8.06 | Drug Central |
D5 | DRD5 | Human | Dopamine | A | pKi | 8.09 | 8.09 | 8.09 | Drug Central |
H1 | HRH1 | Human | Histamine | A | pKi | 8.04 | 8.04 | 8.04 | Drug Central |
D1 | DRD1 | Bovine | Dopamine | A | pKi | 8.11 | 8.11 | 8.11 | Drug Central |
D1 | DRD1 | Human | Dopamine | A | pKi | 7.0 | 7.7 | 8.4 | Guide to Pharmacology |
D3 | DRD3 | Rat | Dopamine | A | pKi | 8.49 | 8.49 | 8.49 | PDSP Ki database |
D1 | DRD1 | Bovine | Dopamine | A | pKi | 7.75 | 7.75 | 7.75 | ChEMBL |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
D1 | DRD1 | Rat | Dopamine | A | pIC50 | 9.52 | 9.52 | 9.52 | ChEMBL |
M1 | ACM1 | Rat | Acetylcholine (muscarinic) | A | Potency | 5.3 | 5.67 | 6.05 | ChEMBL |
D1 | DRD1 | Rat | Dopamine | A | pIC50 | 8.02 | 8.02 | 8.02 | Drug Central |
TSH | TSHR | Human | Glycoprotein hormone | A | Potency | 4.7 | 4.7 | 4.7 | ChEMBL |