GPCRdb

fluspirilene

Agent/drug
Bioactivity

fluspirilene

SMILES	O=C1NCN(c2ccccc2)C12CCN(CCCC(c1ccc(F)cc1)c1ccc(F)cc1)CC2
InChIKey	QOYHHIBFXOOADH-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	1
Rotatable bonds	7
Molecular weight (Da)	475.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.24	6.24	6.24	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.20	8.20	8.20	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	7.32	7.32	7.32	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.14	8.14	8.14	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.14	8.14	8.14	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	7.21	7.21	7.21	PDSP Ki database
β₁	ADRB1	Human	Adrenoceptors	A	pKi	6.23	6.23	6.23	PDSP Ki database
β₁	ADRB1	Human	Adrenoceptors	A	pKi	8.21	8.21	8.21	Drug Central
β₂	ADRB2	Human	Adrenoceptors	A	pKi	6.29	6.29	6.29	PDSP Ki database
β₂	ADRB2	Human	Adrenoceptors	A	pKi	8.20	8.20	8.20	Drug Central
δ	OPRD	Mouse	Opioid	A	pKi	6.00	6.00	6.00	PDSP Ki database
κ	OPRK	Guinea pig	Opioid	A	pKi	6.00	6.00	6.00	PDSP Ki database
μ	OPRM	Rat	Opioid	A	pKi	7.11	7.11	7.11	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	7.20	7.20	7.20	Guide to Pharmacology
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	6.96	6.96	6.96	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	7.25	7.25	7.25	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.14	8.14	8.14	Drug Central
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	5.30	5.30	5.30	PDSP Ki database
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	5.95	5.95	5.95	PDSP Ki database
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	8.23	8.23	8.23	Drug Central

Showing 1 to 20 of 55 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	4.80	4.88	4.95	ChEMBL
NPS	NPSR1	Human	Neuropeptide S	A	Potency	4.90	5.00	5.10	ChEMBL

Showing 1 to 2 of 2 entries

fluspirilene

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Schizophrenia or other primary psychotic disorders, unspecified	6A2Z	N05A	0.615	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z	N05A	0.732	4	Yes

Showing 1 to 2 of 2 entries