codeine


SMILES COc1ccc2c3c1O[C@@H]1[C@@]43CCN([C@H](C2)[C@@H]4C=C[C@@H]1O)C
InChIKey OROGSEYTTFOCAN-DNJOTXNNSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 1
Molecular weight (Da) 299.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
μ OPRM Human Opioid A pKi 6.9 6.9 6.9 Guide to Pharmacology
κ OPRK Human Opioid A pKi 4.59 4.59 4.59 ChEMBL
μ OPRM Human Opioid A pKi 5.2 5.67 6.14 ChEMBL
δ OPRD Human Opioid A pKi 8.37 8.37 8.37 Drug Central
κ OPRK Human Opioid A pKi 8.34 8.34 8.34 Drug Central
μ OPRM Human Opioid A pKi 8.21 8.21 8.21 Drug Central
δ OPRD Human Opioid A pKi 4.28 4.28 4.28 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
κ OPRK Human Opioid A pIC50 4.82 4.82 4.82 ChEMBL
μ OPRM Human Opioid A pEC50 5.21 5.21 5.21 ChEMBL
μ OPRM Human Opioid A pIC50 6.28 6.63 6.98 ChEMBL