NORTRIPTYLINE
| SMILES | CNCCC=C1c2ccccc2CCc2ccccc21 |
| InChIKey | PHVGLTMQBUFIQQ-UHFFFAOYSA-N |
Chemical properties
| Hydrogen bond acceptors | 1 |
| Hydrogen bond donors | 1 |
| Rotatable bonds | 3 |
| Molecular weight (Da) | 263.2 |
Drug properties
| Molecular type | Small molecule |
| Endogenous/Surrogate | Surrogate |
| Approved drug | No |
Database connections
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| 5-HT1B | 5HT1B | Rat | 5-Hydroxytryptamine | A | pKi | 5.84 | 5.84 | 5.84 | ChEMBL |
| α1B | ADA1B | Rat | Adrenoceptors | A | pKi | 6.94 | 6.94 | 6.94 | ChEMBL |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 7.37 | 7.37 | 7.37 | ChEMBL |
| α1A | ADA1A | Rat | Adrenoceptors | A | pKi | 6.91 | 6.91 | 6.91 | ChEMBL |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 7.52 | 7.52 | 7.52 | ChEMBL |
| H2 | HRH2 | Human | Histamine | A | pKi | 5.64 | 5.64 | 5.64 | ChEMBL |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 6.87 | 6.87 | 6.87 | ChEMBL |
| M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pKi | 7.7 | 7.7 | 7.7 | ChEMBL |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 6.56 | 6.56 | 6.56 | ChEMBL |
| M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pKi | 7.89 | 7.89 | 7.89 | ChEMBL |
| H1 | HRH1 | Human | Histamine | A | pKi | 8.23 | 8.23 | 8.23 | ChEMBL |
| M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pKi | 7.44 | 7.44 | 7.44 | ChEMBL |
| 5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pKi | 7.07 | 7.07 | 7.07 | ChEMBL |
| M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pKi | 6.91 | 6.91 | 6.91 | ChEMBL |
| D1 | DRD1 | Human | Dopamine | A | pKi | 6.57 | 6.57 | 6.57 | ChEMBL |
| 5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pKi | 5.97 | 5.97 | 5.97 | ChEMBL |
| M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pKi | 7.7 | 7.7 | 7.7 | ChEMBL |
| 5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pKi | 6.59 | 6.63 | 6.67 | ChEMBL |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 8.09 | 8.09 | 8.09 | ChEMBL |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 7.82 | 7.82 | 7.82 | ChEMBL |
| D3 | DRD3 | Human | Dopamine | A | pKi | 7.21 | 7.21 | 7.21 | ChEMBL |
| 5-HT6 | 5HT6R | Rat | 5-Hydroxytryptamine | A | pKi | 6.83 | 6.83 | 6.83 | PDSP Ki database |
| 5-HT2C | 5HT2C | Rat | 5-Hydroxytryptamine | A | pKi | 8.07 | 8.07 | 8.07 | PDSP Ki database |
| H1 | HRH1 | Human | Histamine | A | pKi | 7.82 | 8.03 | 8.2 | PDSP Ki database |
| 5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 6.53 | 6.53 | 6.53 | PDSP Ki database |
| D2 | DRD2 | Human | Dopamine | A | pKi | 5.59 | 5.59 | 5.59 | PDSP Ki database |
| H1 | HRH1 | Rat | Histamine | A | pKi | 7.34 | 7.34 | 7.34 | PDSP Ki database |
| β2 | ADRB2 | Human | Adrenoceptors | A | pKi | 5.0 | 5.0 | 5.0 | PDSP Ki database |
| M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pKi | 7.4 | 7.4 | 7.4 | PDSP Ki database |
| M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pKi | 7.3 | 7.3 | 7.3 | PDSP Ki database |
| M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pKi | 7.08 | 7.08 | 7.08 | PDSP Ki database |
| M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pKi | 7.01 | 7.01 | 7.01 | PDSP Ki database |
| H1 | HRH1 | Guinea pig | Histamine | A | pKi | 7.52 | 7.52 | 7.52 | PDSP Ki database |
| D2 | DRD2 | Human | Dopamine | A | pKi | 8.25 | 8.25 | 8.25 | Drug Central |
| D1 | DRD1 | Human | Dopamine | A | pKi | 8.18 | 8.18 | 8.18 | Drug Central |
| 5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 8.19 | 8.19 | 8.19 | Drug Central |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 8.13 | 8.13 | 8.13 | Drug Central |
| 5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pKi | 8.15 | 8.15 | 8.15 | Drug Central |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 8.1 | 8.1 | 8.1 | Drug Central |
| M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pKi | 8.13 | 8.13 | 8.13 | Drug Central |
| M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pKi | 8.16 | 8.16 | 8.16 | Drug Central |
| M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pKi | 8.14 | 8.14 | 8.14 | Drug Central |
| M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pKi | 8.15 | 8.15 | 8.15 | Drug Central |
| M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pKi | 8.15 | 8.15 | 8.15 | Drug Central |
| α1A | ADA1A | Human | Adrenoceptors | A | pKi | 8.14 | 8.14 | 8.14 | Drug Central |
| α1D | ADA1D | Human | Adrenoceptors | A | pKi | 8.16 | 8.16 | 8.16 | Drug Central |
| α2A | ADA2A | Human | Adrenoceptors | A | pKi | 8.18 | 8.18 | 8.18 | Drug Central |
| α2B | ADA2B | Human | Adrenoceptors | A | pKi | 8.15 | 8.15 | 8.15 | Drug Central |
| α2C | ADA2C | Human | Adrenoceptors | A | pKi | 8.12 | 8.12 | 8.12 | Drug Central |
| D3 | DRD3 | Human | Dopamine | A | pKi | 8.14 | 8.14 | 8.14 | Drug Central |
| H1 | HRH1 | Human | Histamine | A | pKd | 8.1 | 8.1 | 8.1 | Drug Central |
| H2 | HRH2 | Human | Histamine | A | pKi | 8.25 | 8.25 | 8.25 | Drug Central |
| 5-HT1B | 5HT1B | Rat | 5-Hydroxytryptamine | A | pKi | 8.23 | 8.23 | 8.23 | Drug Central |
| 5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pKi | 8.18 | 8.18 | 8.18 | Drug Central |
| M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pKi | 6.96 | 6.96 | 6.96 | PDSP Ki database |
| α1B | ADA1B | Rat | Adrenoceptors | A | pKi | 8.16 | 8.16 | 8.16 | Drug Central |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| H1 | HRH1 | Rat | Histamine | A | pIC50 | 10.3 | 10.3 | 10.3 | ChEMBL |
| 5-HT1B | 5HT1B | Rat | 5-Hydroxytryptamine | A | pIC50 | 5.5 | 5.5 | 5.5 | ChEMBL |
| α1B | ADA1B | Rat | Adrenoceptors | A | pIC50 | 6.68 | 6.68 | 6.68 | ChEMBL |
| α2B | ADA2B | Human | Adrenoceptors | A | pIC50 | 7.03 | 7.03 | 7.03 | ChEMBL |
| α1A | ADA1A | Rat | Adrenoceptors | A | pIC50 | 6.52 | 8.46 | 10.4 | ChEMBL |
| M1 | ACM1 | Rat | Acetylcholine (muscarinic) | A | Potency | 5.75 | 6.28 | 6.8 | ChEMBL |
| α2C | ADA2C | Human | Adrenoceptors | A | pIC50 | 6.69 | 6.69 | 6.69 | ChEMBL |
| H2 | HRH2 | Human | Histamine | A | pIC50 | 5.63 | 5.63 | 5.63 | ChEMBL |
| α1D | ADA1D | Human | Adrenoceptors | A | pIC50 | 6.56 | 6.56 | 6.56 | ChEMBL |
| M5 | ACM5 | Human | Acetylcholine (muscarinic) | A | pIC50 | 7.57 | 7.57 | 7.57 | ChEMBL |
| α2A | ADA2A | Human | Adrenoceptors | A | pIC50 | 6.13 | 6.13 | 6.13 | ChEMBL |
| M4 | ACM4 | Human | Acetylcholine (muscarinic) | A | pIC50 | 7.02 | 7.02 | 7.02 | ChEMBL |
| H1 | HRH1 | Human | Histamine | A | pIC50 | 7.3 | 7.3 | 7.3 | ChEMBL |
| M3 | ACM3 | Human | Acetylcholine (muscarinic) | A | pIC50 | 6.77 | 6.77 | 6.77 | ChEMBL |
| 5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pIC50 | 6.87 | 6.87 | 6.87 | ChEMBL |
| M2 | ACM2 | Human | Acetylcholine (muscarinic) | A | pIC50 | 6.46 | 6.46 | 6.46 | ChEMBL |
| D1 | DRD1 | Human | Dopamine | A | pIC50 | 6.27 | 6.27 | 6.27 | ChEMBL |
| 5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pIC50 | 5.73 | 5.73 | 5.73 | ChEMBL |
| M1 | ACM1 | Human | Acetylcholine (muscarinic) | A | pIC50 | 7.09 | 7.09 | 7.09 | ChEMBL |
| 5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pIC50 | 6.26 | 6.26 | 6.26 | ChEMBL |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pIC50 | 7.8 | 7.8 | 7.8 | ChEMBL |
| 5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pIC50 | 7.29 | 7.29 | 7.29 | ChEMBL |
| D3 | DRD3 | Human | Dopamine | A | pIC50 | 6.75 | 6.75 | 6.75 | ChEMBL |
| TSH | TSHR | Human | Glycoprotein hormone | A | Potency | 5.1 | 5.1 | 5.1 | ChEMBL |
| 5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pIC50 | 8.24 | 8.24 | 8.24 | Drug Central |
| α1A | ADA1A | Rat | Adrenoceptors | A | pIC50 | 7.98 | 7.98 | 7.98 | Drug Central |
| H1 | HRH1 | Rat | Histamine | A | pIC50 | 7.99 | 7.99 | 7.99 | Drug Central |
| NPS | NPSR1 | Human | Neuropeptide S | A | Potency | 7.1 | 7.1 | 7.1 | ChEMBL |