CHEMBL4595327


SMILES CN(C)[C@@H]1CCN(c2ccnc(NCC(C)(C)C)n2)C1
InChIKey QLLZULWFESFQOY-GFCCVEGCSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 4
Molecular weight (Da) 277.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H4 HRH4 Mouse Histamine A pKd 7.47 7.63 7.82 ChEMBL
H4 HRH4 Mouse Histamine A pKi 6.31 6.91 7.51 ChEMBL
H4 HRH4 Rat Histamine A pKd 7.47 7.56 7.66 ChEMBL
H4 HRH4 Rat Histamine A pKi 5.71 5.71 5.71 ChEMBL
H4 HRH4 Human Histamine A pKi 6.45 7.55 7.93 ChEMBL
H4 HRH4 Human Histamine A pKd 7.23 7.32 7.44 ChEMBL
H3 HRH3 Human Histamine A pKi 6.3 6.36 6.84 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H4 HRH4 Mouse Histamine A pEC50 5.1 7.08 8.99 ChEMBL
H4 HRH4 Rat Histamine A pEC50 4.3 6.97 9.19 ChEMBL
H4 HRH4 Human Histamine A pEC50 7.73 8.23 8.72 ChEMBL