CHEMBL4476699


SMILES CCc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1Cl
InChIKey DRRONPWFEYCYOF-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 8
Molecular weight (Da) 439.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D4 DRD4 Human Dopamine A pKi 6.45 6.45 6.45 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.73 7.73 7.73 ChEMBL
D3 DRD3 Human Dopamine A pKi 9.81 9.81 9.81 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.62 8.62 8.62 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 7.58 7.58 7.58 ChEMBL
D2 DRD2 Human Dopamine A pKi 8.2 8.2 8.2 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D3 DRD3 Human Dopamine A pIC50 7.73 7.73 7.73 ChEMBL
D3 DRD3 Human Dopamine A pEC50 6.39 6.39 6.39 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pEC50 7.51 7.51 7.51 ChEMBL