Chembl4802733

Chemical Properties

SMILES N[C@@]1(C(=O)O)[C@H](CSc2ccc(F)c(F)c2)[C@@H](O)[C@@H]2[C@H]1[C@H]2C(=O)O
Hydrogen bond acceptors 5
Hydrogen bond donors 4
Rotatable bonds 5
Molecular weight 359.1

Drug Properties

Type Small molecule
Endogenous No
Approved No
InChIKey PVCLSZDVATUGHR-XJDZXMJWSA-N

Database Connections

External Links


Bioactivity

Receptor Experimental Data Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu8 GRM8 Human Metabotropic glutamate C pEC50 5.75 5.75 5.75 ChEMBL
mGlu6 GRM6 Human Metabotropic glutamate C pIC50 5.4 5.4 5.4 ChEMBL
mGlu3 GRM3 Human Metabotropic glutamate C pIC50 8.21 8.41 8.6 ChEMBL
mGlu3 GRM3 Human Metabotropic glutamate C pKi 8.6 8.6 8.6 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pIC50 7.79 8.09 8.39 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pKi 8.28 8.28 8.28 ChEMBL