GSK-189254


SMILES CNC(=O)c1ccc(nc1)Oc1ccc2c(c1)CCN(CC2)C1CCC1
InChIKey WROHEWWOCPRMIA-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 4
Molecular weight (Da) 351.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H3 HRH3 Human Histamine A pKi 9.7 9.7 9.7 Guide to Pharmacology
H3 HRH3 Rat Histamine A pKi 8.58 8.98 9.2 ChEMBL
H3 HRH3 Human Histamine A pKi 9.59 9.77 9.92 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H3 HRH3 Human Histamine A pIC50 9.26 9.26 9.26 ChEMBL