CHEMBL494709


SMILES O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1
InChIKey RIZPYDSXCAUQAK-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 10
Molecular weight (Da) 442.3

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 9.01 9.01 9.01 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 7.16 7.16 7.16 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.73 6.73 6.73 ChEMBL
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 9.01 9.01 9.01 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 7.15 7.15 7.15 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 6.73 6.73 6.73 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT7 5HT7R Guinea pig 5-Hydroxytryptamine A pEC50 6.51 6.51 6.51 ChEMBL