RS-127445


SMILES Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C
InChIKey ZZZQXCUPAJFVBN-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 2
Molecular weight (Da) 281.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
ETB EDNRB Human Endothelin A pKd 8.1 8.1 8.1 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
ETA EDNRA Human Endothelin A pIC50 5.0 5.04 5.09 ChEMBL
ETB EDNRB Human Endothelin A pIC50 7.92 8.05 8.19 ChEMBL