fluprostenol


SMILES OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O
InChIKey WWSWYXNVCBLWNZ-QIZQQNKQSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 4
Rotatable bonds 11
Molecular weight (Da) 458.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
ghrelin GHSR Human Ghrelin A pKd 9.85 9.85 9.85 ChEMBL
ghrelin GHSR Human Ghrelin A pKi 9.62 9.62 9.62 ChEMBL
ghrelin GHSR Human Ghrelin A pKi 9.34 9.34 9.34 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
ghrelin GHSR Human Ghrelin A pIC50 6.52 8.55 9.4 ChEMBL
ghrelin GHSR Human Ghrelin A pEC50 8.85 9.19 9.7 ChEMBL
ghrelin GHSR Human Ghrelin A pEC50 8.62 9.17 9.72 Guide to Pharmacology
ghrelin GHSR Rat Ghrelin A pEC50 8.89 8.89 8.89 ChEMBL
GHRH GHRHR Rat Glucagon B1 pEC50 8.82 8.82 8.82 ChEMBL