ICI198615


SMILES COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1
InChIKey YRCPIXCRSAKRGM-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 8
Molecular weight (Da) 548.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
CysLT1 CLTR1 Guinea pig Leukotriene A pKi 9.7 9.7 9.7 Guide to Pharmacology
CysLT1 CLTR1 Human Leukotriene A pKd 10.6 10.6 10.6 Guide to Pharmacology
CysLT2 CLTR2 Human Leukotriene A pKd 5.2 5.2 5.2 Guide to Pharmacology
CysLT1 CLTR1 Guinea pig Leukotriene A pKd 4.52 4.52 4.52 ChEMBL
CysLT1 CLTR1 Guinea pig Leukotriene A pKi 9.52 9.52 9.52 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database