latanoprost (isopropyl ester)


SMILES O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O
InChIKey GGXICVAJURFBLW-CEYXHVGTSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 13
Molecular weight (Da) 432.3

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
DP1 PD2R Human Prostanoid A pKi 5.0 5.0 5.0 PDSP Ki database
EP1 PE2R1 Human Prostanoid A pKi 8.24 8.24 8.24 Drug Central
EP1 PE2R1 Human Prostanoid A pKi 5.07 5.42 5.76 PDSP Ki database
EP3 PE2R3 Human Prostanoid A pKi 8.29 8.29 8.29 Drug Central
EP3 PE2R3 Human Prostanoid A pKi 5.0 5.1 5.19 PDSP Ki database
EP4 PE2R4 Human Prostanoid A pKi 5.0 5.0 5.0 PDSP Ki database
FP PF2R Human Prostanoid A pKi 8.2 8.2 8.2 Drug Central
FP PF2R Human Prostanoid A pKi 6.26 7.41 8.55 PDSP Ki database
FP PF2R Human Prostanoid A pKi 6.3 6.3 6.3 Guide to Pharmacology
IP PI2R Human Prostanoid A pKi 5.0 5.0 5.0 PDSP Ki database
FP PF2R Bovine Prostanoid A pKi 8.15 8.15 8.15 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database