Isoprenaline


SMILES CC(NCC(c1ccc(c(c1)O)O)O)C
InChIKey JWZZKOKVBUJMES-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 4
Rotatable bonds 4
Molecular weight (Da) 211.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Bioactivity

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
β1 ADRB1 Human Adrenoceptors A pKi 6.6 6.8 7.0 Guide to Pharmacology
β2 ADRB2 Human Adrenoceptors A pKi 6.4 6.4 6.4 Guide to Pharmacology
β3 ADRB3 Rat Adrenoceptors A pKi 5.3 5.3 5.3 Guide to Pharmacology
β3 ADRB3 Mouse Adrenoceptors A pKi 4.2 4.75 5.3 Guide to Pharmacology
β3 ADRB3 Human Adrenoceptors A pKi 5.1 5.65 6.2 Guide to Pharmacology
TAS2R42 T2R42 Human Taste 2 T pEC50 8.31 8.31 8.31 ChEMBL
TAS2R60 T2R60 Human Taste 2 T pEC50 8.31 8.31 8.31 ChEMBL
TAS2R45 T2R45 Human Taste 2 T pEC50 8.31 8.31 8.31 ChEMBL
TAS2R20 T2R20 Human Taste 2 T pEC50 8.31 8.31 8.31 ChEMBL
TAS2R40 T2R40 Human Taste 2 T pEC50 8.31 8.31 8.31 ChEMBL
TAS2R5 TA2R5 Human Taste 2 T pEC50 8.31 8.31 8.31 ChEMBL
TAS2R50 T2R50 Human Taste 2 T pEC50 8.31 8.31 8.31 ChEMBL
TAS2R30 T2R30 Human Taste 2 T pEC50 8.31 8.31 8.31 ChEMBL
TAS2R3 TA2R3 Human Taste 2 T pEC50 8.31 8.31 8.31 ChEMBL
TAS2R13 T2R13 Human Taste 2 T pEC50 8.31 8.31 8.31 ChEMBL
TAS2R4 TA2R4 Human Taste 2 T pEC50 8.31 8.31 8.31 ChEMBL
TAS2R9 TA2R9 Human Taste 2 T pEC50 8.31 8.31 8.31 ChEMBL
TAS2R43 T2R43 Human Taste 2 T pEC50 8.31 8.31 8.31 ChEMBL
TAS2R19 T2R19 Human Taste 2 T pEC50 8.31 8.31 8.31 ChEMBL
TAS2R7 TA2R7 Human Taste 2 T pEC50 8.31 8.31 8.31 ChEMBL
TAS2R38 T2R38 Human Taste 2 T pEC50 8.31 8.31 8.31 ChEMBL
TAS2R1 TA2R1 Human Taste 2 T pEC50 8.31 8.31 8.31 ChEMBL
TAS2R39 T2R39 Human Taste 2 T pEC50 8.31 8.31 8.31 ChEMBL
TAS2R10 T2R10 Human Taste 2 T pEC50 8.31 8.31 8.31 ChEMBL
β1 ADRB1 Mouse Adrenoceptors A pKi 6.66 6.66 6.66 ChEMBL
TAS2R41 T2R41 Human Taste 2 T pEC50 8.31 8.31 8.31 ChEMBL
TAS2R31 T2R31 Human Taste 2 T pEC50 8.31 8.31 8.31 ChEMBL
TAS2R16 T2R16 Human Taste 2 T pEC50 8.31 8.31 8.31 ChEMBL
TAS2R46 T2R46 Human Taste 2 T pEC50 8.31 8.31 8.31 ChEMBL
β2 ADRB2 Rat Adrenoceptors A pIC50 10.0 10.0 10.0 ChEMBL
TAS2R14 T2R14 Human Taste 2 T pEC50 8.31 8.31 8.31 ChEMBL
β2 ADRB2 Bovine Adrenoceptors A pKd 6.48 6.48 6.48 ChEMBL
β2 ADRB2 Bovine Adrenoceptors A pKi 6.96 6.96 6.96 ChEMBL
β2 ADRB2 Dog Adrenoceptors A pIC50 6.0 8.67 10.0 ChEMBL
β3 ADRB3 Rat Adrenoceptors A pEC50 7.06 7.47 7.89 ChEMBL
TAS2R8 TA2R8 Human Taste 2 T pEC50 8.31 8.31 8.31 ChEMBL
β1 ADRB1 Rat Adrenoceptors A pIC50 6.22 7.25 8.28 ChEMBL
β1 ADRB1 Rat Adrenoceptors A pKi 6.17 6.79 7.1 ChEMBL
β1 B0FL73 Guinea pig Adrenoceptors A pEC50 8.22 8.22 8.22 ChEMBL
β2 ADRB2 Guinea pig Adrenoceptors A pEC50 7.24 7.56 8.1 ChEMBL
β2 ADRB2 Guinea pig Adrenoceptors A pKd 7.6 7.67 7.75 ChEMBL
β1 ADRB1 Human Adrenoceptors A pEC50 6.0 8.65 10.08 ChEMBL
β1 ADRB1 Human Adrenoceptors A pKi 5.8 6.25 6.71 ChEMBL
β1 ADRB1 Human Adrenoceptors A pIC50 6.48 6.48 6.48 ChEMBL
β3 ADRB3 Human Adrenoceptors A pEC50 6.0 7.82 9.01 ChEMBL
β3 ADRB3 Human Adrenoceptors A pKi 4.73 4.73 4.73 ChEMBL
RXFP1 RXFP1 Human Relaxin family peptide A Potency 5.5 5.5 5.5 ChEMBL
D4 DRD4 Human Dopamine A pKi 5.54 5.54 5.54 ChEMBL
β2 ADRB2 Human Adrenoceptors A pEC50 6.0 8.11 10.26 ChEMBL
β2 ADRB2 Human Adrenoceptors A pKi 6.17 6.89 8.61 ChEMBL
β2 ADRB2 Human Adrenoceptors A pKd 6.13 6.73 7.3 ChEMBL
β2 ADRB2 Human Adrenoceptors A pIC50 6.61 6.61 6.61 ChEMBL
D3 DRD3 Human Dopamine A pKi 5.33 5.33 5.33 ChEMBL
D2 DRD2 Human Dopamine A pKi 4.32 4.62 4.92 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 6.4 6.4 6.4 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 4.0 4.0 4.0 PDSP Ki database
β1 B0FL73 Guinea pig Adrenoceptors A pKi 5.33 5.33 5.33 PDSP Ki database
β2 ADRB2 Guinea pig Adrenoceptors A pKi 5.49 5.73 5.97 PDSP Ki database
β2 ADRB2 Human Adrenoceptors A pKi 4.82 5.02 5.34 PDSP Ki database
β2 ADRB2 Greater long-tailed hamster Adrenoceptors A pKi 4.55 5.45 6.34 PDSP Ki database
α2A ADA2A Pig Adrenoceptors A pKi 4.0 4.0 4.0 PDSP Ki database
β1 ADRB1 Human Adrenoceptors A pKi 5.65 5.65 5.65 PDSP Ki database
β3 ADRB3 Human Adrenoceptors A pKi 4.8 4.8 4.8 PDSP Ki database
α2A ADA2A Mouse Adrenoceptors A pKi 4.0 4.0 4.0 PDSP Ki database
β1 ADRB1 Rat Adrenoceptors A pIC50 7.21 7.21 7.21 Drug Central
β1 ADRB1 Human Adrenoceptors A pEC50 7.05 7.05 7.05 Drug Central
β2 ADRB2 Human Adrenoceptors A pEC50 7.01 7.01 7.01 Drug Central
D2 DRD2 Human Dopamine A pKi 7.31 7.31 7.31 Drug Central
D3 DRD3 Human Dopamine A pKi 7.27 7.27 7.27 Drug Central
β3 ADRB3 Human Adrenoceptors A pEC50 7.07 7.07 7.07 Drug Central
D4 DRD4 Human Dopamine A pKi 7.26 7.26 7.26 Drug Central
β2 ADRB2 Guinea pig Adrenoceptors A pEC50 7.12 7.12 7.12 Drug Central
β2 ADRB2 Bovine Adrenoceptors A pKd 7.19 7.19 7.19 Drug Central
β2 ADRB2 Dog Adrenoceptors A pIC50 7.22 7.22 7.22 Drug Central
TAS2R14 T2R14 Human Taste 2 T pEC50 7.08 7.08 7.08 Drug Central
TAS2R46 T2R46 Human Taste 2 T pEC50 7.08 7.08 7.08 Drug Central
β2 ADRB2 Golden hamster Adrenoceptors A pKi 7.16 7.16 7.16 Drug Central
β3 ADRB3 Mouse Adrenoceptors A pKi 7.28 7.28 7.28 Drug Central
β3 ADRB3 Rat Adrenoceptors A pKi 7.28 7.28 7.28 Drug Central
β1 ADRB1 Mouse Adrenoceptors A pKi 7.18 7.18 7.18 Drug Central
TAS2R38 T2R38 Human Taste 2 T pEC50 7.08 7.08 7.08 Drug Central
TAS2R39 T2R39 Human Taste 2 T pEC50 7.08 7.08 7.08 Drug Central
TAS2R40 T2R40 Human Taste 2 T pEC50 7.08 7.08 7.08 Drug Central
TAS2R41 T2R41 Human Taste 2 T pEC50 7.08 7.08 7.08 Drug Central
TAS2R43 T2R43 Human Taste 2 T pEC50 7.08 7.08 7.08 Drug Central
TAS2R31 T2R31 Human Taste 2 T pEC50 7.08 7.08 7.08 Drug Central
TAS2R45 T2R45 Human Taste 2 T pEC50 7.08 7.08 7.08 Drug Central
TAS2R30 T2R30 Human Taste 2 T pEC50 7.08 7.08 7.08 Drug Central
TAS2R19 T2R19 Human Taste 2 T pEC50 7.08 7.08 7.08 Drug Central
TAS2R20 T2R20 Human Taste 2 T pEC50 7.08 7.08 7.08 Drug Central
TAS2R50 T2R50 Human Taste 2 T pEC50 7.08 7.08 7.08 Drug Central
TAS2R60 T2R60 Human Taste 2 T pEC50 7.08 7.08 7.08 Drug Central
TAS2R42 T2R42 Human Taste 2 T pEC50 7.08 7.08 7.08 Drug Central
TAS2R16 T2R16 Human Taste 2 T pEC50 7.08 7.08 7.08 Drug Central
TAS2R13 T2R13 Human Taste 2 T pEC50 7.08 7.08 7.08 Drug Central
TAS2R10 T2R10 Human Taste 2 T pEC50 7.08 7.08 7.08 Drug Central
TAS2R9 TA2R9 Human Taste 2 T pEC50 7.08 7.08 7.08 Drug Central
TAS2R8 TA2R8 Human Taste 2 T pEC50 7.08 7.08 7.08 Drug Central
TAS2R7 TA2R7 Human Taste 2 T pEC50 7.08 7.08 7.08 Drug Central
TAS2R5 TA2R5 Human Taste 2 T pEC50 7.08 7.08 7.08 Drug Central
TAS2R4 TA2R4 Human Taste 2 T pEC50 7.08 7.08 7.08 Drug Central
TAS2R3 TA2R3 Human Taste 2 T pEC50 7.08 7.08 7.08 Drug Central
TAS2R1 TA2R1 Human Taste 2 T pEC50 7.08 7.08 7.08 Drug Central