GPCRdb

idazoxan

Agent/drug
Bioactivity

idazoxan

SMILES	c1ccc2c(c1)OCC(C1=NCCN1)O2
InChIKey	HPMRFMKYPGXPEP-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	1
Rotatable bonds	1
Molecular weight (Da)	204.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank PubChem GPCRdb
Ligand site mutations	α_2A

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Bovine	Adrenoceptors	A	pKi	6.30	6.30	6.30	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	7.20	7.20	7.20	Guide to Pharmacology
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.10	8.13	8.15	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.01	8.28	8.72	PDSP Ki database
α_2A	ADA2A	Bovine	Adrenoceptors	A	pKi	8.82	8.82	8.82	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.40	6.40	6.40	Guide to Pharmacology
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	7.00	7.43	7.64	ChEMBL
α_2B	ADA2B	Rat	Adrenoceptors	A	pKi	8.33	8.33	8.33	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	7.00	7.21	7.43	PDSP Ki database
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	7.20	7.20	7.20	Guide to Pharmacology
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	7.72	7.74	7.75	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	7.70	8.22	9.25	PDSP Ki database
α_2C	ADA2C	North American opossum	Adrenoceptors	A	pKi	8.62	8.62	8.62	PDSP Ki database
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	6.79	6.81	6.84	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	6.18	6.18	6.18	PDSP Ki database
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_2C	K7GSR7	Pig	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT₇	5HT7R	Rat	5-Hydroxytryptamine	A	pKi	6.00	6.00	6.00	PDSP Ki database
D₁	DRD1	Human	Dopamine	A	pKi	5.00	5.00	5.00	PDSP Ki database

Showing 1 to 20 of 22 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pIC50	5.54	5.54	5.54	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	8.08	8.08	8.08	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	7.71	7.71	7.71	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	7.27	7.27	7.27	ChEMBL
NPS	NPSR1	Human	Neuropeptide S	A	Potency	5.00	5.00	5.00	ChEMBL

Showing 1 to 5 of 5 entries

idazoxan

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 0

Phase II 6

Phase III 0

Phase IV 0

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank PubChem GPCRdb
Ligand site mutations	α_2A

Sankey plot

Drug Information

Search:

Target					Disease

Gene	Protein	Receptor family	Ligand type	Class	Name	Phase	ICD11	ATC	Association score

ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Alzheimer disease	2	8A20		0.271
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Schizophrenia, episode unspecified	2	6A20.Z		0.544
ADA2B	α_2B-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Alzheimer disease	2	8A20		0.389
ADA2B	α_2B-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Schizophrenia, episode unspecified	2	6A20.Z		0.525
ADA2C	α_2C-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Alzheimer disease	2	8A20		0.289
ADA2C	α_2C-adrenoceptor	Adrenoceptors	Aminergic receptors	A	Schizophrenia, episode unspecified	2	6A20.Z		0.543

Showing 1 to 6 of 6 entries