GPCRdb

MITOXANTRONE

Agent/drug
Bioactivity

MITOXANTRONE

SMILES	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21
InChIKey	KKZJGLLVHKMTCM-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	10
Hydrogen bond donors	8
Rotatable bonds	12
Molecular weight (Da)	444.2

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	5.73	5.73	5.73	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.24	8.24	8.24	Drug Central
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pKi	6.74	6.74	6.74	ChEMBL
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pKi	8.17	8.17	8.17	Drug Central
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pKi	7.11	7.11	7.11	ChEMBL
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pKi	8.15	8.15	8.15	Drug Central
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pKi	7.05	7.05	7.05	ChEMBL
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pKi	8.15	8.15	8.15	Drug Central

Showing 1 to 8 of 8 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	5.45	5.45	5.45	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	4.75	5.03	5.30	ChEMBL
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pIC50	6.13	6.13	6.13	ChEMBL
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pIC50	6.66	6.66	6.66	ChEMBL
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pIC50	6.19	6.19	6.19	ChEMBL
NPS	NPSR1	Human	Neuropeptide S	A	Potency	5.00	5.00	5.00	ChEMBL

Showing 1 to 6 of 6 entries

MITOXANTRONE

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved No

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids PubChem GPCRdb

Compound is not listed as a drug.