GPCRdb

imipramine

Agent/drug
Bioactivity

imipramine

SMILES	CN(C)CCCN1c2ccccc2CCc2ccccc21
InChIKey	BCGWQEUPMDMJNV-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	0
Rotatable bonds	4
Molecular weight (Da)	280.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1D	ADA1D	Human	Adrenoceptors	A	pKi	7.49	7.49	7.49	PDSP Ki database
β₂	ADRB2	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.00	5.12	5.24	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.28	8.28	8.28	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	6.80	6.92	7.03	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.17	8.17	8.17	Drug Central
5-HT_2C	5HT2C	Mouse	5-Hydroxytryptamine	A	pKi	6.80	6.80	6.80	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	6.80	6.80	6.80	ChEMBL
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	6.80	6.95	7.03	PDSP Ki database
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	6.92	6.92	6.92	PDSP Ki database
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.17	8.17	8.17	Drug Central
5-HT_2C	5HT2C	Mouse	5-Hydroxytryptamine	A	pKi	8.17	8.17	8.17	Drug Central
5-HT₆	5HT6R	Rat	5-Hydroxytryptamine	A	pKi	6.68	6.70	6.72	PDSP Ki database
5-HT₇	5HT7R	Rat	5-Hydroxytryptamine	A	pKi	6.00	6.00	6.00	PDSP Ki database
D₁	DRD1	Bovine	Dopamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
D₁	DRD1	Rat	Dopamine	A	pKi	5.52	5.52	5.52	PDSP Ki database
D₁	DRD1	Human	Dopamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
D₂	DRD2	Mouse	Dopamine	A	pKi	6.14	6.14	6.14	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	6.14	6.14	6.14	ChEMBL

Showing 1 to 20 of 42 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pIC50	8.13	8.13	8.13	Drug Central
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	8.06	8.06	8.06	Drug Central
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	8.77	8.77	8.77	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	8.15	8.15	8.15	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	6.66	6.66	6.66	ChEMBL
A₃	AA3R	Human	Adenosine	A	pIC50	8.08	8.08	8.08	Drug Central
D₂	DRD2	Human	Dopamine	A	pIC50	6.39	6.39	6.39	ChEMBL
H₁	HRH1	Rat	Histamine	A	pIC50	10.22	10.22	10.22	ChEMBL
H₁	HRH1	Human	Histamine	A	pIC50	7.57	7.57	7.57	ChEMBL
H₁	HRH1	Human	Histamine	A	pIC50	8.12	8.12	8.12	Drug Central
H₁	HRH1	Rat	Histamine	A	pIC50	7.99	7.99	7.99	Drug Central
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	6.00	6.22	6.45	ChEMBL
M₅	ACM5	Rat	Acetylcholine (muscarinic)	A	pIC50	6.52	6.52	6.52	ChEMBL
M₅	ACM5	Rat	Acetylcholine (muscarinic)	A	pIC50	8.19	8.19	8.19	Drug Central

Showing 1 to 14 of 14 entries

imipramine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved No

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central GPCRdb

Compound is not listed as a drug.