GPCRdb

SCH-23390

SMILES	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1
InChIKey	GOTMKOSCLKVOGG-OAHLLOKOSA-N

Chemical properties

Hydrogen bond acceptors	2
Hydrogen bond donors	1
Rotatable bonds	1
Molecular weight (Da)	287.1

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	No

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids ChEMBL_compound_ids PubChem GPCRdb
Ligand site mutations	D₁ D₂ D₅

Search:

Receptor					Activity				Source
GTP No matches found	Uniprot No matches found	Species No matches found	Family No matches found	Class No matches found	Type No matches found	Min	Avg	Max	Database No matches found
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	6.58	6.58	6.58	PDSP Ki database
5-HT_1A	A0A4X1UTF5	Pig	5-Hydroxytryptamine	A	pKi	6.47	6.47	6.47	PDSP Ki database
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	5.0	5.0	5.0	PDSP Ki database
5-HT_1D	F1MMU1	Bovine	5-Hydroxytryptamine	A	pKi	5.4	5.43	5.5	PDSP Ki database
5-HT_2A	5HT2A	Rat	5-Hydroxytryptamine	A	pKi	7.7	7.95	8.07	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	7.88	7.88	7.88	PDSP Ki database
5-HT_2B	5HT2B	Rat	5-Hydroxytryptamine	A	pKi	7.08	7.08	7.08	PDSP Ki database
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	7.15	7.15	7.15	PDSP Ki database
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	7.9	7.9	7.9	ChEMBL
5-HT_2C	K7GSR7	Pig	5-Hydroxytryptamine	A	pKi	5.27	7.86	8.3	PDSP Ki database
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	7.87	7.87	7.87	PDSP Ki database
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	7.39	7.39	7.39	PDSP Ki database
5-HT₆	5HT6R	Mouse	5-Hydroxytryptamine	A	pKi	5.6	5.6	5.6	PDSP Ki database
D₁	DRD1	Mouse	Dopamine	A	pKi	9.4	9.4	9.4	ChEMBL
D₁	DRD1	Goldfish	Dopamine	A	pKi	8.89	8.89	8.89	ChEMBL
D₁	DRD1	Pig	Dopamine	A	pKi	9.3	9.3	9.3	ChEMBL
D₁	DRD1	Bovine	Dopamine	A	pKi	7.43	8.75	10.0	ChEMBL
D₁	DRD1	Rat	Dopamine	A	pKi	6.17	9.19	9.92	ChEMBL
D₁	DRD1	Human	Dopamine	A	pKi	7.62	9.38	10.0	ChEMBL
D₁	DRD1	Human	Dopamine	A	pKd	9.42	9.42	9.42	ChEMBL
D₁	DRD1	Bovine	Dopamine	A	pKi	5.0	7.12	9.24	PDSP Ki database
D₁	DRD1	Rat	Dopamine	A	pKi	6.75	9.3	9.92	PDSP Ki database
D₁	DRD1	Human	Dopamine	A	pKi	9.46	9.46	9.46	PDSP Ki database
D₁	DRD1	Mouse	Dopamine	A	pKi	9.85	9.85	9.85	PDSP Ki database
D₁	DRD1	Rhesus macaque	Dopamine	A	pKi	8.89	9.05	9.22	PDSP Ki database
D₂	DRD2	Mouse	Dopamine	A	pKi	5.92	5.92	5.92	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pKi	6.05	6.52	9.27	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	6.0	6.03	6.05	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pKi	5.25	5.72	6.44	PDSP Ki database
D₂	DRD2	Human	Dopamine	A	pKi	5.67	5.86	6.04	PDSP Ki database
D₂	DRD2	Mouse	Dopamine	A	pKi	6.05	6.05	6.05	PDSP Ki database
D₃	DRD3	Rat	Dopamine	A	pKi	6.12	6.12	6.12	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	5.0	5.0	5.0	PDSP Ki database
D₄	DRD4	Human	Dopamine	A	pKi	5.45	5.45	5.45	PDSP Ki database
D₅	DRD5	Human	Dopamine	A	pKi	8.09	9.05	9.77	ChEMBL
D₅	DRD5	Rat	Dopamine	A	pKi	9.0	9.16	9.33	PDSP Ki database
D₅	DRD5	Human	Dopamine	A	pKi	9.52	9.52	9.52	PDSP Ki database
H₁	HRH1	Human	Histamine	A	pKi	7.0	7.0	7.0	PDSP Ki database

Showing 1 to 38 of 38 entries

Search:

Receptor					Activity				Source
GTP No matches found	Uniprot No matches found	Species No matches found	Family No matches found	Class No matches found	Type No matches found	Min	Avg	Max	Database No matches found
D₁	DRD1	Rat	Dopamine	A	pIC50	8.37	8.9	9.24	ChEMBL
D₁	DRD1	Human	Dopamine	A	pIC50	6.28	8.57	9.66	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pIC50	5.72	5.97	6.22	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	5.69	6.93	7.59	ChEMBL
D₅	DRD5	Human	Dopamine	A	pIC50	8.96	9.4	9.82	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	4.6	4.6	4.6	ChEMBL

Showing 1 to 6 of 6 entries

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Main reference

SCH-23390

Chemical properties

Drug properties

Database connections

Bioactivities