ISOLOXAPINE


SMILES CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ccccc32)CC1
InChIKey AWHNHDGHHNGACT-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 0
Molecular weight (Da) 327.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations H4

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 7.72 7.72 7.72 ChEMBL
H4 HRH4 Human Histamine A pKi 7.37 7.37 7.37 ChEMBL
D4 DRD4 Human Dopamine A pKi 7.64 7.64 7.64 ChEMBL
D2 DRD2 Rat Dopamine A pKi 6.82 6.82 6.82 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.82 6.82 6.82 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H4 HRH4 Human Histamine A pEC50 7.55 7.55 7.55 ChEMBL