(R)-α-methylhistamine
| SMILES | C[C@H](Cc1cnc[nH]1)N |
| InChIKey | XNQIOISZPFVUFG-RXMQYKEDSA-N |
Chemical properties
| Hydrogen bond acceptors | 2 |
| Hydrogen bond donors | 2 |
| Rotatable bonds | 2 |
| Molecular weight (Da) | 125.1 |
Drug properties
| Molecular type | Small molecule |
| Endogenous/Surrogate | Surrogate |
| Approved drug | No |
Database connections
| Ligand site mutations | H3 |
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| H3 | HRH3 | Human | Histamine | A | pKi | 8.4 | 8.8 | 9.2 | Guide to Pharmacology |
| H3 | HRH3 | Human | Histamine | A | pKd | 9.2 | 9.2 | 9.2 | Guide to Pharmacology |
| H4 | HRH4 | Mouse | Histamine | A | pKi | 6.4 | 6.4 | 6.4 | Guide to Pharmacology |
| H4 | HRH4 | Rat | Histamine | A | pKi | 6.2 | 6.2 | 6.2 | Guide to Pharmacology |
| H3 | HRH3 | Rat | Histamine | A | pKi | 8.0 | 8.35 | 8.7 | Guide to Pharmacology |
| H3 | HRH3 | Mouse | Histamine | A | pKi | 8.4 | 8.4 | 8.4 | Guide to Pharmacology |
| H4 | HRH4 | Human | Histamine | A | pKd | 7.2 | 7.2 | 7.2 | Guide to Pharmacology |
| H4 | HRH4 | Human | Histamine | A | pKi | 6.5 | 6.7 | 6.9 | Guide to Pharmacology |
| H3 | HRH3 | Guinea pig | Histamine | A | pKi | 8.82 | 9.38 | 10.07 | ChEMBL |
| H3 | HRH3 | Guinea pig | Histamine | A | pKd | 7.8 | 7.8 | 7.8 | ChEMBL |
| H4 | HRH4 | Human | Histamine | A | pKi | 6.6 | 6.73 | 6.84 | ChEMBL |
| H3 | HRH3 | Human | Histamine | A | pKi | 7.2 | 8.61 | 9.26 | ChEMBL |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| H3 | HRH3 | Rat | Histamine | A | pIC50 | 8.82 | 8.82 | 8.82 | ChEMBL |
| H4 | HRH4 | Human | Histamine | A | pEC50 | 5.95 | 6.08 | 6.2 | ChEMBL |
| H3 | HRH3 | Human | Histamine | A | pEC50 | 7.4 | 8.65 | 9.5 | ChEMBL |
| H3 | HRH3 | Human | Histamine | A | pIC50 | 8.64 | 8.64 | 8.64 | ChEMBL |