CHEMBL62444


SMILES CC(C)(C)[C@H]1CC[C@H](N(Cc2ccc(C(=O)NCCC(=O)O)cc2)C(=O)Nc2ccc(OC(F)(F)F)cc2)CC1
InChIKey BZXMLCVDKDXRQY-AFARHQOCSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 9
Molecular weight (Da) 563.3

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
glucagon GLR Human Glucagon B1 pKi 7.2 7.2 7.2 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
glucagon GLR Rat Glucagon B1 pIC50 7.25 7.25 7.25 ChEMBL
GIP GIPR Human Glucagon B1 pIC50 5.89 5.89 5.89 ChEMBL
glucagon GLR Human Glucagon B1 pIC50 6.85 7.26 7.68 ChEMBL
GLP-1 GLP1R Human Glucagon B1 pIC50 6.0 6.0 6.0 ChEMBL