CYCLOBENZAPRINE


SMILES CN(C)CCC=C1c2ccccc2C=Cc2ccccc21
InChIKey JURKNVYFZMSNLP-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 3
Molecular weight (Da) 275.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections


Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.12 8.12 8.12 Drug Central
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.17 8.17 8.17 Drug Central
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.14 8.14 8.14 Drug Central
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.17 8.17 8.17 Drug Central
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 8.17 8.17 8.17 Drug Central
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 8.14 8.14 8.14 Drug Central
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 8.09 8.09 8.09 Drug Central
H1 HRH1 Human Histamine A pKi 8.05 8.05 8.05 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 6.95 7.22 7.5 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 5.1 5.1 5.1 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pIC50 8.16 8.16 8.16 Drug Central