TP-040n
SMILES | CN1CCN(c2ccnc(NCCc3ccccc3)n2)CC1 |
InChIKey | BNXNWRSVYQHTOH-UHFFFAOYSA-N |
Chemical properties
Hydrogen bond acceptors | None |
Hydrogen bond donors | None |
Rotatable bonds | None |
Molecular weight (Da) |
Drug properties
Molecular type | Na |
Endogenous/Surrogate | Surrogate |
Approved drug | No |
Database connections
Bioactivities
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
5-HT5A | 5HT5A | Human | 5-Hydroxytryptamine | A | pKi | 5.21 | 5.25 | 5.29 | ChEMBL |
5-HT1D | 5HT1D | Human | 5-Hydroxytryptamine | A | pKi | 5.69 | 5.71 | 5.74 | ChEMBL |
H4 | HRH4 | Human | Histamine | A | pKi | 6.15 | 6.15 | 6.15 | ChEMBL |
α2B | ADA2B | Human | Adrenoceptors | A | pKi | 6.32 | 6.35 | 6.37 | ChEMBL |
α2C | ADA2C | Human | Adrenoceptors | A | pKi | 6.38 | 6.38 | 6.39 | ChEMBL |
H2 | HRH2 | Human | Histamine | A | pKi | 6.83 | 6.83 | 6.84 | ChEMBL |
5-HT7 | 5HT7R | Human | 5-Hydroxytryptamine | A | pKi | 6.48 | 6.48 | 6.48 | ChEMBL |
5-HT6 | 5HT6R | Human | 5-Hydroxytryptamine | A | pKi | 6.22 | 6.22 | 6.22 | ChEMBL |
5-HT2B | 5HT2B | Human | 5-Hydroxytryptamine | A | pKi | 6.54 | 6.54 | 6.55 | ChEMBL |
H3 | HRH3 | Human | Histamine | A | pKi | 7.03 | 7.06 | 7.09 | ChEMBL |
5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 6.57 | 6.58 | 6.59 | ChEMBL |
5-HT2A | 5HT2A | Human | 5-Hydroxytryptamine | A | pKi | 6.12 | 6.14 | 6.16 | ChEMBL |
Receptor | Activity | Source | |||||||
---|---|---|---|---|---|---|---|---|---|
GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |