FK 888


SMILES CN1C=C(C2=CC=CC=C21)C(=O)N3CC(CC3C(=O)NC(CC4=CC5=CC=CC=C5C=C4)C(=O)N(C)CC6=CC=CC=C6)O
InChIKey BFNKQTIJVFGCKQ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 8
Molecular weight (Da) 588.3

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NK1 NK1R Human Tachykinin A pKi 8.83 8.83 8.83 PDSP Ki database
NK2 NK2R Human Tachykinin A pKi 5.82 5.82 5.82 PDSP Ki database
NK3 NK3R Guinea pig Tachykinin A pKi 5.25 5.25 5.25 PDSP Ki database
NK1 NK1R Guinea pig Tachykinin A pKi 8.5 8.5 8.5 PDSP Ki database
NK1 NK1R Rat Tachykinin A pKi 5.68 5.68 5.68 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database