JNJ-42153605


SMILES FC(c1c(ccn2c1nnc2CC1CC1)N1CCC(CC1)c1ccccc1)(F)F
InChIKey BQAVZGJJQFJSMW-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 4
Molecular weight (Da) 400.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Human Metabotropic glutamate C pKi 7.82 7.82 7.82 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pKi 7.82 7.82 7.82 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Human Metabotropic glutamate C pEC50 6.42 7.36 8.32 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pIC50 7.82 7.82 7.82 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pEC50 7.77 7.77 7.77 Guide to Pharmacology