JNJ-5207852


SMILES C1CCN(CC1)CCCOc1ccc(cc1)CN1CCCCC1
InChIKey PTKHFRNHJULJKT-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 7
Molecular weight (Da) 316.3

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H3 HRH3 Human Histamine A pKi 8.03 9.23 10.22 ChEMBL
H3 HRH3 Human Histamine A pKd 9.08 9.69 9.84 ChEMBL
H3 HRH3 Human Histamine A pKi 9.22 9.22 9.22 PDSP Ki database
H3 HRH3 Human Histamine A pKi 9.2 9.2 9.2 Guide to Pharmacology
H3 HRH3 Rat Histamine A pKi 8.9 9.1 9.34 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H3 HRH3 Human Histamine A pIC50 9.28 9.28 9.28 ChEMBL