L-366,509


SMILES OC(=O)CC1(O)CC2C(C1(CC2)CS(=O)(=O)N1CCC2(CC1)C=Cc1c2cccc1)(C)C
InChIKey XKVDTEPESVJNPJ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 5
Molecular weight (Da) 459.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu8 GRM8 Human Metabotropic glutamate C pKd 6.6 6.65 6.7 Guide to Pharmacology
mGlu4 GRM4 Rat Metabotropic glutamate C pKd 6.3 6.3 6.3 Guide to Pharmacology
mGlu8 GRM8 Rat Metabotropic glutamate C pKi 5.72 5.72 5.72 ChEMBL
mGlu8 GRM8 Human Metabotropic glutamate C pKi 7.21 7.21 7.21 ChEMBL
mGlu6 GRM6 Human Metabotropic glutamate C pKi 6.05 6.05 6.05 ChEMBL
mGlu4 GRM4 Rat Metabotropic glutamate C pKi 6.8 6.8 6.8 ChEMBL
mGlu4 GRM4 Human Metabotropic glutamate C pKi 6.04 6.39 6.8 ChEMBL
mGlu7 GRM7 Human Metabotropic glutamate C pKi 3.7 3.7 3.7 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu4 GRM4 Human Metabotropic glutamate C pEC50 6.5 6.5 6.5 Guide to Pharmacology
mGlu6 GRM6 Human Metabotropic glutamate C pEC50 6.7 7.0 7.3 Guide to Pharmacology
mGlu8 GRM8 Human Metabotropic glutamate C pIC50 7.0 7.1 7.2 Guide to Pharmacology
mGlu8 GRM8 Rat Metabotropic glutamate C pEC50 6.2 6.2 6.2 Guide to Pharmacology
mGlu4 GRM4 Rat Metabotropic glutamate C pIC50 6.0 6.2 6.4 Guide to Pharmacology
mGlu8 GRM8 Mouse Metabotropic glutamate C pEC50 6.4 6.4 6.4 ChEMBL
mGlu6 GRM6 Rat Metabotropic glutamate C pEC50 5.46 6.08 7.26 ChEMBL
mGlu8 GRM8 Rat Metabotropic glutamate C pEC50 6.52 6.89 7.22 ChEMBL
mGlu7 GRM7 Human Metabotropic glutamate C pEC50 3.73 3.73 3.73 ChEMBL
mGlu8 GRM8 Human Metabotropic glutamate C pEC50 6.25 6.64 7.22 ChEMBL
mGlu6 GRM6 Human Metabotropic glutamate C pEC50 5.62 6.29 7.26 ChEMBL
mGlu4 GRM4 Rat Metabotropic glutamate C pEC50 5.92 6.68 7.52 ChEMBL
mGlu4 GRM4 Human Metabotropic glutamate C pEC50 6.16 6.59 7.0 ChEMBL
mGlu7 GRM7 Human Metabotropic glutamate C pEC50 3.8 3.8 3.8 Guide to Pharmacology