PACAP-38
| SMILES | None |
| InChIKey | None |
| Sequence | HSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNK |
Chemical properties
| Hydrogen bond acceptors | None |
| Hydrogen bond donors | None |
| Rotatable bonds | None |
| Molecular weight (Da) |
Drug properties
| Molecular type | Peptide |
| Endogenous/Surrogate | Endogenous |
| Approved drug | No |
Database connections
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| mGlu2 | GRM2 | Human | Metabotropic glutamate | C | pKi | 6.3 | 6.3 | 6.3 | Guide to Pharmacology |
| mGlu3 | GRM3 | Human | Metabotropic glutamate | C | pKi | 7.4 | 7.4 | 7.4 | Guide to Pharmacology |
| mGlu7 | GRM7 | Human | Metabotropic glutamate | C | pKi | 4.3 | 4.3 | 4.3 | Guide to Pharmacology |
| mGlu3 | GRM3 | Rat | Metabotropic glutamate | C | pKi | 6.5 | 6.5 | 6.5 | Guide to Pharmacology |
| mGlu2 | GRM2 | Rat | Metabotropic glutamate | C | pKi | 6.8 | 6.9 | 7.0 | Guide to Pharmacology |
| mGlu1 | GRM1 | Rat | Metabotropic glutamate | C | pKi | 5.6 | 5.6 | 5.6 | Guide to Pharmacology |
| mGlu8 | GRM8 | Human | Metabotropic glutamate | C | pKi | 5.47 | 5.47 | 5.47 | ChEMBL |
| mGlu6 | GRM6 | Human | Metabotropic glutamate | C | pKi | 5.24 | 5.24 | 5.24 | ChEMBL |
| mGlu1 | GRM1 | Human | Metabotropic glutamate | C | pKi | 4.3 | 4.3 | 4.3 | ChEMBL |
| mGlu4 | GRM4 | Human | Metabotropic glutamate | C | pKi | 4.3 | 4.3 | 4.3 | ChEMBL |
| mGlu2 | GRM2 | Human | Metabotropic glutamate | C | pKi | 6.31 | 6.31 | 6.31 | ChEMBL |
| mGlu5 | GRM5 | Human | Metabotropic glutamate | C | pKi | 5.51 | 5.51 | 5.51 | ChEMBL |
| mGlu3 | GRM3 | Human | Metabotropic glutamate | C | pKi | 6.36 | 6.36 | 6.36 | ChEMBL |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| mGlu6 | GRM6 | Human | Metabotropic glutamate | C | pEC50 | 6.2 | 6.2 | 6.2 | Guide to Pharmacology |
| mGlu8 | GRM8 | Human | Metabotropic glutamate | C | pIC50 | 6.1 | 6.2 | 6.3 | Guide to Pharmacology |
| mGlu5 | GRM5 | Rat | Metabotropic glutamate | C | pIC50 | 5.8 | 5.8 | 5.8 | Guide to Pharmacology |
| mGlu6 | GRM6 | Rat | Metabotropic glutamate | C | pEC50 | 5.2 | 5.2 | 5.2 | Guide to Pharmacology |
| mGlu8 | GRM8 | Rat | Metabotropic glutamate | C | pEC50 | 6.2 | 6.2 | 6.2 | Guide to Pharmacology |
| mGlu4 | GRM4 | Rat | Metabotropic glutamate | C | pIC50 | 4.3 | 4.65 | 5.0 | Guide to Pharmacology |
| mGlu6 | GRM6 | Rat | Metabotropic glutamate | C | pEC50 | 6.22 | 6.22 | 6.22 | ChEMBL |
| mGlu8 | GRM8 | Rat | Metabotropic glutamate | C | pEC50 | 6.4 | 6.4 | 6.4 | ChEMBL |
| mGlu7 | GRM7 | Rat | Metabotropic glutamate | C | pEC50 | 4.33 | 4.33 | 4.33 | ChEMBL |
| mGlu4 | GRM4 | Rat | Metabotropic glutamate | C | pEC50 | 5.4 | 5.4 | 5.4 | ChEMBL |
| mGlu3 | GRM3 | Rat | Metabotropic glutamate | C | pEC50 | 6.22 | 6.22 | 6.22 | ChEMBL |
| mGlu1 | GRM1 | Rat | Metabotropic glutamate | C | pEC50 | 4.64 | 4.64 | 4.64 | ChEMBL |
| mGlu2 | GRM2 | Rat | Metabotropic glutamate | C | pEC50 | 6.12 | 6.32 | 6.52 | ChEMBL |
| mGlu2 | GRM2 | Human | Metabotropic glutamate | C | pEC50 | 6.42 | 6.42 | 6.42 | ChEMBL |
| mGlu5 | GRM5 | Rat | Metabotropic glutamate | C | pEC50 | 4.77 | 4.77 | 4.77 | ChEMBL |