[Leu]enkephalin


SMILES None
InChIKey URLZCHNOLZSCCA-UHFFFAOYSA-N
Sequence YGGFL

Chemical properties

Hydrogen bond acceptors None
Hydrogen bond donors None
Rotatable bonds None
Molecular weight (Da)

Drug properties

Molecular type Peptide
Endogenous/Surrogate Endogenous
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
δ OPRD Human Opioid A pKi 8.7 8.7 8.7 Guide to Pharmacology
μ OPRM Human Opioid A pKi 8.1 8.1 8.1 Guide to Pharmacology
δ OPRD Mouse Opioid A pKi 8.4 8.4 8.4 Guide to Pharmacology
κ OPRK Rat Opioid A pKi 6.0 6.0 6.0 Guide to Pharmacology
δ O57585 Zebrafish Opioid A pKi 7.14 7.14 7.14 ChEMBL
δ OPRD Mouse Opioid A pKi 8.16 8.18 8.2 ChEMBL
μ OPRM Rat Opioid A pKi 7.56 8.05 8.62 ChEMBL
δ OPRD Human Opioid A pKi 7.51 8.56 9.15 ChEMBL
μ OPRM Human Opioid A pKi 5.32 7.6 8.69 ChEMBL
μ OPRM Human Opioid A pKi 8.13 8.26 8.47 PDSP Ki database
δ OPRD Human Opioid A pKi 8.4 8.94 9.74 PDSP Ki database
κ OPRK Human Opioid A pKi 5.0 5.5 6.0 PDSP Ki database
κ OPRK Guinea pig Opioid A pKi 5.0 5.17 5.34 PDSP Ki database
δ A0A286XTF2 Guinea pig Opioid A pKi 8.8 8.8 8.8 PDSP Ki database
μ OPRM Mouse Opioid A pKi 8.04 8.11 8.18 PDSP Ki database
δ OPRD Mouse Opioid A pKi 8.6 8.6 8.6 PDSP Ki database
κ OPRK Guinea pig Opioid A pKi 5.34 5.34 5.34 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
δ OPRD Mouse Opioid A pIC50 7.65 8.34 8.97 ChEMBL
δ OPRD Mouse Opioid A pEC50 7.13 7.13 7.13 ChEMBL
μ OPRM Rat Opioid A pIC50 7.3 7.3 7.3 ChEMBL
δ OPRD Human Opioid A pEC50 6.92 8.42 10.1 ChEMBL
κ OPRK Human Opioid A pEC50 7.1 7.1 7.1 ChEMBL
μ OPRM Human Opioid A pEC50 5.89 7.07 8.89 ChEMBL
μ OPRM Human Opioid A pIC50 5.02 5.02 5.02 ChEMBL
μ OPRM Mouse Opioid A pIC50 7.7 7.81 8.03 ChEMBL