GPCRdb

laropiprant

Agent/drug
Bioactivity

laropiprant

SMILES	CS(=O)(=O)c1cc(F)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3
InChIKey	NXFFJDQHYLNEJK-CYBMUJFWSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	1
Rotatable bonds	5
Molecular weight (Da)	435.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central DrugBank GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

D₃	DRD3	Human	Dopamine	A	pKi	5.95	5.95	5.95	ChEMBL
DP₁	PD2R	Human	Prostanoid	A	pKd	7.98	7.98	7.98	Drug Central
DP₁	PD2R	Human	Prostanoid	A	pKd	10.52	10.52	10.52	ChEMBL
DP₁	PD2R	Human	Prostanoid	A	pKi	9.24	9.24	9.24	ChEMBL
DP₂	PD2R2	Human	Prostanoid	A	pKi	8.21	8.21	8.21	Drug Central
DP₂	PD2R2	Human	Prostanoid	A	pKi	6.13	6.13	6.13	ChEMBL
EP₁	PE2R1	Human	Prostanoid	A	pKi	5.94	5.94	5.94	ChEMBL
EP₁	PE2R1	Human	Prostanoid	A	pKi	8.23	8.23	8.23	Drug Central
EP₂	PE2R2	Human	Prostanoid	A	pKi	8.16	8.16	8.16	Drug Central
EP₂	PE2R2	Human	Prostanoid	A	pKi	6.87	6.87	6.87	ChEMBL
EP₃	PE2R3	Human	Prostanoid	A	pKi	6.05	6.05	6.05	ChEMBL
EP₃	PE2R3	Human	Prostanoid	A	pKi	8.22	8.22	8.22	Drug Central
FP	PF2R	Human	Prostanoid	A	pKi	8.30	8.30	8.30	Drug Central
FP	PF2R	Human	Prostanoid	A	pKi	5.00	5.00	5.00	ChEMBL
IP	PI2R	Human	Prostanoid	A	pKi	8.29	8.29	8.29	Drug Central
IP	PI2R	Human	Prostanoid	A	pKi	5.18	5.18	5.18	ChEMBL
TP	TA2R	Human	Prostanoid	A	pKd	7.96	7.96	7.96	ChEMBL
TP	TA2R	Human	Prostanoid	A	pKi	8.53	8.53	8.53	ChEMBL
TP	TA2R	Human	Prostanoid	A	pKi	8.07	8.07	8.07	Drug Central
TP	TA2R	Human	Prostanoid	A	pKi	6.10	6.10	6.10	Guide to Pharmacology

Showing 1 to 20 of 20 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

DP₁	PD2R	Human	Prostanoid	A	pIC50	8.40	9.10	10.05	ChEMBL
TP	TA2R	Human	Prostanoid	A	pIC50	6.11	6.11	6.11	ChEMBL

Showing 1 to 2 of 2 entries

laropiprant

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved No

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central DrugBank GPCRdb

Compound is not listed as a drug.