LY341495


SMILES OC(=O)[C@H]1C[C@@H]1[C@](C(=O)O)(CC1c2ccccc2Oc2c1cccc2)N
InChIKey VLZBRVJVCCNPRJ-KPHUOKFYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 5
Molecular weight (Da) 353.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Structure pdb 7MTQ 7FD9 7WI6 7WI8

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu1 GRM1 Human Metabotropic glutamate C pKi 7.8 7.8 7.8 Guide to Pharmacology
mGlu2 GRM2 Human Metabotropic glutamate C pKi 8.6 8.6 8.6 Guide to Pharmacology
mGlu2 GRM2 Human Metabotropic glutamate C pKd 8.8 8.8 8.8 Guide to Pharmacology
mGlu3 GRM3 Human Metabotropic glutamate C pKi 8.9 8.9 8.9 Guide to Pharmacology
mGlu3 GRM3 Human Metabotropic glutamate C pKd 9.1 9.1 9.1 Guide to Pharmacology
mGlu7 GRM7 Human Metabotropic glutamate C pKi 6.7 6.7 6.7 Guide to Pharmacology
mGlu7 GRM7 Human Metabotropic glutamate C pKd 7.1 7.1 7.1 Guide to Pharmacology
mGlu3 GRM3 Rat Metabotropic glutamate C pKi 8.0 8.0 8.0 Guide to Pharmacology
mGlu3 GRM3 Rat Metabotropic glutamate C pKd 7.3 7.3 7.3 Guide to Pharmacology
mGlu2 GRM2 Rat Metabotropic glutamate C pKi 7.7 8.35 9.0 Guide to Pharmacology
mGlu7 GRM7 Human Metabotropic glutamate C pKi 6.0 6.0 6.0 ChEMBL
mGlu8 GRM8 Human Metabotropic glutamate C pKi 6.77 6.77 6.77 ChEMBL
mGlu7 GRM7 Rat Metabotropic glutamate C pKi 6.96 6.96 6.96 ChEMBL
mGlu3 GRM3 Human Metabotropic glutamate C pKi 7.85 8.37 8.89 ChEMBL
mGlu3 GRM3 Rat Metabotropic glutamate C pKi 8.52 8.52 8.52 ChEMBL
mGlu2 GRM2 Rat Metabotropic glutamate C pKi 8.5 8.5 8.5 ChEMBL
mGlu1 GRM1 Human Metabotropic glutamate C pKi 5.17 5.17 5.17 ChEMBL
mGlu4 GRM4 Human Metabotropic glutamate C pKi 4.66 4.66 4.66 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pKi 7.68 8.02 8.37 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pKi 5.09 5.09 5.09 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu4 GRM4 Human Metabotropic glutamate C pIC50 4.7 4.7 4.7 Guide to Pharmacology
mGlu5 GRM5 Human Metabotropic glutamate C pIC50 5.1 5.1 5.1 Guide to Pharmacology
mGlu8 GRM8 Human Metabotropic glutamate C pIC50 6.8 6.8 6.8 Guide to Pharmacology
mGlu6 GRM6 Human Metabotropic glutamate C pEC50 4.5 4.5 4.5 Guide to Pharmacology
mGlu6 GRM6 Rat Metabotropic glutamate C pIC50 5.94 5.94 5.94 ChEMBL
mGlu7 GRM7 Human Metabotropic glutamate C pIC50 6.0 6.0 6.0 ChEMBL
mGlu8 GRM8 Human Metabotropic glutamate C pIC50 6.77 6.77 6.77 ChEMBL
mGlu4 GRM4 Rat Metabotropic glutamate C pIC50 5.58 5.58 5.58 ChEMBL
mGlu3 GRM3 Human Metabotropic glutamate C pIC50 7.85 8.13 8.55 ChEMBL
mGlu3 GRM3 Rat Metabotropic glutamate C pIC50 7.8 7.82 7.85 ChEMBL
mGlu1 GRM1 Rat Metabotropic glutamate C pIC50 5.05 5.05 5.05 ChEMBL
mGlu2 GRM2 Rat Metabotropic glutamate C pIC50 6.7 7.17 7.63 ChEMBL
mGlu1 GRM1 Human Metabotropic glutamate C pIC50 5.11 5.11 5.11 ChEMBL
mGlu4 GRM4 Human Metabotropic glutamate C pIC50 4.66 4.66 4.66 ChEMBL
mGlu2 GRM2 Human Metabotropic glutamate C pIC50 6.7 7.71 8.54 ChEMBL
mGlu5 GRM5 Rat Metabotropic glutamate C pIC50 4.94 4.94 4.94 ChEMBL
mGlu5 GRM5 Human Metabotropic glutamate C pIC50 5.09 5.09 5.09 ChEMBL