LY3154885


SMILES C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl
InChIKey MJDOWJUPBHLXIH-GOEBONIOSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 4
Molecular weight (Da) 443.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D1 DRD1 Human Dopamine A pEC50 7.93 7.93 7.93 Guide to Pharmacology
D5 DRD5 Mouse Dopamine A pEC50 5.75 6.04 6.32 ChEMBL
D1 DRD1 Mouse Dopamine A pEC50 6.82 6.82 6.82 ChEMBL
D1 DRD1 Human Dopamine A pEC50 7.79 7.86 7.93 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pEC50 6.0 6.0 6.0 ChEMBL