CHEMBL1259241


SMILES Cc1ccc(CNCC2(F)CCN(C(=O)c3csc4ccccc34)CC2)nc1
InChIKey TXTILBTZVJQWSG-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 5
Molecular weight (Da) 397.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2A 5HT2A Pig 5-Hydroxytryptamine A pKi 4.66 4.66 4.66 ChEMBL
D1 DRD1 Pig Dopamine A pKi 4.35 4.35 4.35 ChEMBL
D4 DRD4 Human Dopamine A pKi 6.34 6.34 6.34 ChEMBL
D3 DRD3 Human Dopamine A pKi 5.06 5.06 5.06 ChEMBL
D2 DRD2 Human Dopamine A pKi 4.27 4.48 4.7 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pEC50 8.0 8.0 8.0 ChEMBL