GPCRdb

mepyramine

Agent/drug
Bioactivity

mepyramine

SMILES	COc1ccc(CN(CCN(C)C)c2ccccn2)cc1
InChIKey	YECBIJXISLIIDS-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	0
Rotatable bonds	7
Molecular weight (Da)	285.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central Guide To Pharmacology PubChem GPCRdb
Structure pdb	8X63
Ligand site mutations	H₁

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.95	5.95	5.95	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.23	8.23	8.23	Drug Central
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	6.54	6.54	6.54	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	5.70	5.70	5.70	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.24	8.24	8.24	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	5.75	5.75	5.75	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.24	8.24	8.24	Drug Central
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	6.23	6.23	6.23	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.21	8.21	8.21	Drug Central
H₁	HRH1	Human	Histamine	A	pKi	8.70	8.85	9.00	Guide to Pharmacology
H₁	HRH1	Guinea pig	Histamine	A	pKd	8.84	9.12	9.50	ChEMBL
H₁	HRH1	Human	Histamine	A	pKi	8.35	8.85	9.37	ChEMBL
H₁	HRH1	Human	Histamine	A	pKi	5.00	8.43	9.28	PDSP Ki database
H₁	HRH1	Guinea pig	Histamine	A	pKi	8.90	9.14	9.30	PDSP Ki database
H₁	HRH1	Rat	Histamine	A	pKi	8.35	8.35	8.35	PDSP Ki database
H₁	HRH1	Mouse	Histamine	A	pKi	8.49	8.49	8.49	PDSP Ki database
H₁	HRH1	Human	Histamine	A	pKi	8.04	8.04	8.04	Drug Central
H₁	HRH1	Guinea pig	Histamine	A	pKd	8.02	8.02	8.02	Drug Central
H₃	HRH3	Rat	Histamine	A	pKi	5.00	5.03	5.10	PDSP Ki database

Showing 1 to 20 of 21 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	5.53	5.53	5.53	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	6.00	6.00	6.00	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	5.55	5.55	5.55	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	5.95	5.95	5.95	ChEMBL
A₃	AA3R	Human	Adenosine	A	pIC50	8.05	8.05	8.05	Drug Central
H₁	HRH1	Rat	Histamine	A	pIC50	8.24	8.24	8.24	ChEMBL
H₁	HRH1	Guinea pig	Histamine	A	pIC50	7.47	8.14	8.82	ChEMBL
H₁	HRH1	Human	Histamine	A	pIC50	6.80	8.51	10.85	ChEMBL
H₁	HRH1	Human	Histamine	A	pEC50	8.59	8.59	8.59	ChEMBL
H₁	HRH1	Rat	Histamine	A	pIC50	8.08	8.08	8.08	Drug Central
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	4.80	4.88	4.95	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	4.40	4.83	5.30	ChEMBL

Showing 1 to 12 of 12 entries

mepyramine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central Guide To Pharmacology PubChem GPCRdb
Structure pdb	8X63
Ligand site mutations	H₁

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic or hypersensitivity conditions of unspecified type	4A8Z		0.494	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Allergic rhinitis due to other seasonal allergens	CA08.01		0.610	4	Yes
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	Class A	Pruritus, unspecified	EC90.Z		0.602	4	Yes

Showing 1 to 3 of 3 entries