GPCRdb

metoclopramide

Agent/drug
Bioactivity

metoclopramide

SMILES	CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC
InChIKey	TTWJBBZEZQICBI-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	2
Rotatable bonds	7
Molecular weight (Da)	299.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	D₂ D₄

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pKi	5.99	5.99	5.99	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.22	8.22	8.22	Drug Central
β₂	ADRB2	Rat	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1D	F1MMU1	Bovine	5-Hydroxytryptamine	A	pKi	5.05	5.05	5.05	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	5.98	5.98	5.98	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.22	8.22	8.22	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	6.40	6.40	6.40	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.19	8.19	8.19	Drug Central
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	5.90	5.90	5.90	ChEMBL
5-HT_2C	K7GSR7	Pig	5-Hydroxytryptamine	A	pKi	5.40	5.40	5.40	PDSP Ki database
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	5.00	5.21	5.41	PDSP Ki database
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.23	8.23	8.23	Drug Central
5-HT₄	5HT4R	Mouse	5-Hydroxytryptamine	A	pKi	6.00	6.00	6.00	Guide to Pharmacology
5-HT₄	5HT4R	Rat	5-Hydroxytryptamine	A	pKi	6.01	6.02	6.05	ChEMBL
5-HT₄	5HT4R	Mouse	5-Hydroxytryptamine	A	pKi	5.40	5.62	6.05	PDSP Ki database
5-HT₄	5HT4R	Guinea pig	5-Hydroxytryptamine	A	pKi	6.20	6.25	6.30	PDSP Ki database
5-HT₄	5HT4R	Guinea pig	5-Hydroxytryptamine	A	pKi	8.20	8.20	8.20	Drug Central
5-HT₄	5HT4R	Rat	5-Hydroxytryptamine	A	pKi	8.22	8.22	8.22	Drug Central

Showing 1 to 20 of 38 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	5.57	5.57	5.57	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	5.43	5.43	5.43	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	6.20	6.20	6.20	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	5.62	5.62	5.62	ChEMBL
5-HT₄	5HT4R	Rat	5-Hydroxytryptamine	A	pEC50	5.72	5.91	6.10	ChEMBL
5-HT₄	5HT4R	Human	5-Hydroxytryptamine	A	pEC50	8.22	8.22	8.22	Drug Central
5-HT₄	5HT4R	Human	5-Hydroxytryptamine	A	pEC50	6.10	6.10	6.10	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pIC50	6.09	6.25	6.35	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	6.90	6.90	6.90	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	6.70	6.70	6.70	ChEMBL
D₃	DRD3	Rat	Dopamine	A	pIC50	8.14	8.14	8.14	Drug Central
D₃	DRD3	Rat	Dopamine	A	pIC50	7.21	7.21	7.21	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	7.45	7.45	7.45	ChEMBL

Showing 1 to 13 of 13 entries

metoclopramide

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 15

Phase III 15

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb
Ligand site mutations	D₂ D₄

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

5HT4R	5-HT₄ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Diseases of the digestive system, unspecified	DE2Z	A03F	0.520	4	Yes
5HT4R	5-HT₄ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Gastroenteritis or colitis without specification of origin	1A40.0	A03F	0.507	3	Yes
5HT4R	5-HT₄ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Gastrointestinal bleeding, unspecified	ME24.9Z	A03F	0.442	2	Yes
5HT4R	5-HT₄ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Gastroparesis	DA41.00	A03F	0.561	4	Yes
5HT4R	5-HT₄ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Gastroschisis	LB02	A03F	0.259	3	Yes
5HT4R	5-HT₄ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Headache, not elsewhere classified	MB4D	A03F	0.442	3	Yes
5HT4R	5-HT₄ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Hypoglycaemia without associated diabetes	5A41	A03F	0.074	2	Yes
5HT4R	5-HT₄ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Migraine, unspecified	8A80.Z	A03F	0.572	3	Yes
5HT4R	5-HT₄ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Mild hyperemesis gravidarum	JA60.0	A03F	0.074	2	Yes
5HT4R	5-HT₄ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Nausea or vomiting	MD90	A03F	0.467	4	Yes
5HT4R	5-HT₄ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Other specified obstruction of large intestine	DB30.Y	A03F	0.074	2	Yes
5HT4R	5-HT₄ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Sepsis without septic shock	1G40	A03F	0.129	3	Yes
5HT4R	5-HT₄ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Vomiting	MD90.1	A03F	0.539	4	Yes
ACM1	M₁ receptor	Acetylcholine receptors (muscarinic)	Aminergic receptors	Class A	Diseases of the digestive system, unspecified	DE2Z	A03F	0.583	4	Yes
ACM1	M₁ receptor	Acetylcholine receptors (muscarinic)	Aminergic receptors	Class A	Headache, not elsewhere classified	MB4D	A03F	0.498	3	Yes
ACM1	M₁ receptor	Acetylcholine receptors (muscarinic)	Aminergic receptors	Class A	Hypoglycaemia without associated diabetes	5A41	A03F	0.023	2	Yes
ACM1	M₁ receptor	Acetylcholine receptors (muscarinic)	Aminergic receptors	Class A	Migraine, unspecified	8A80.Z	A03F	0.004	3	Yes
ACM1	M₁ receptor	Acetylcholine receptors (muscarinic)	Aminergic receptors	Class A	Nausea or vomiting	MD90	A03F	0.514	4	Yes
ACM1	M₁ receptor	Acetylcholine receptors (muscarinic)	Aminergic receptors	Class A	Sepsis without septic shock	1G40	A03F	0.007	3	Yes
ACM1	M₁ receptor	Acetylcholine receptors (muscarinic)	Aminergic receptors	Class A	Vomiting	MD90.1	A03F	0.370	4	Yes

Showing 1 to 20 of 33 entries

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metoclopramide

metoclopramide

Chemical Properties

Database connections

Bioactivities

metoclopramide

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information