Naloxone


SMILES C=CCN1CC[C@@]23[C@@]4([C@H]1Cc1c3c(O[C@H]2C(=O)CC4)c(cc1)O)O
InChIKey UZHSEJADLWPNLE-GRGSLBFTSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 2
Molecular weight (Da) 327.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Bioactivity

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
δ OPRD Human Opioid A pKi 7.2 7.2 7.2 Guide to Pharmacology
δ OPRD Mouse Opioid A pIC50 6.2 6.2 6.2 Guide to Pharmacology
δ OPRD Mouse Opioid A pKi 7.8 7.8 7.8 Guide to Pharmacology
κ OPRK Mouse Opioid A pIC50 8.3 8.3 8.3 Guide to Pharmacology
κ OPRK Human Opioid A pKi 7.6 8.1 8.6 Guide to Pharmacology
κ OPRK Rat Opioid A pKi 7.7 7.85 8.0 Guide to Pharmacology
μ OPRM Human Opioid A pKi 8.9 8.9 8.9 Guide to Pharmacology
μ OPRM Mouse Opioid A pKi 9.0 9.0 9.0 Guide to Pharmacology
μ OPRM Rat Opioid A pKd 8.55 8.78 9.0 Guide to Pharmacology
CCR5 CCR5 Mouse Chemokine A pKd 7.68 7.83 7.98 ChEMBL
μ OPRM Bovine Opioid A pIC50 8.3 8.3 8.3 ChEMBL
κ OPRK Mouse Opioid A pKd 6.9 6.9 6.9 ChEMBL
κ OPRK Rat Opioid A pKd 8.35 8.68 9.0 ChEMBL
μ OPRM Mouse Opioid A pKd 7.99 7.99 7.99 ChEMBL
μ OPRM Mouse Opioid A pIC50 7.81 7.81 7.81 ChEMBL
δ OPRD Mouse Opioid A pKd 7.3 7.32 7.35 ChEMBL
δ OPRD Rat Opioid A pKd 7.75 7.75 7.75 ChEMBL
δ OPRD Rat Opioid A pKi 6.99 8.07 8.62 ChEMBL
κ OPRK Guinea pig Opioid A pKi 7.18 8.01 8.51 ChEMBL
κ OPRK Guinea pig Opioid A pIC50 7.3 7.3 7.3 ChEMBL
κ OPRK Guinea pig Opioid A pKd 7.7 7.7 7.7 ChEMBL
μ OPRM Rat Opioid A pKi 8.2 8.6 8.97 ChEMBL
μ OPRM Rat Opioid A pKd 8.3 8.74 9.4 ChEMBL
δ OPRD Human Opioid A pKi 5.82 7.19 7.72 ChEMBL
δ OPRD Human Opioid A pIC50 5.83 6.84 7.21 ChEMBL
κ OPRK Human Opioid A pKi 6.44 8.2 9.6 ChEMBL
κ OPRK Human Opioid A pIC50 6.21 7.08 8.82 ChEMBL
κ OPRK Human Opioid A pEC50 8.0 8.09 8.18 ChEMBL
μ OPRM Human Opioid A pKi 6.45 8.44 9.64 ChEMBL
μ OPRM Human Opioid A pIC50 7.02 7.97 8.73 ChEMBL
μ OPRM Human Opioid A pKd 9.66 9.66 9.66 ChEMBL
μ OPRM Human Opioid A pKi 5.0 7.34 8.18 PDSP Ki database
δ OPRD Human Opioid A pKi 5.0 6.05 6.77 PDSP Ki database
δ A0A286XTF2 Guinea pig Opioid A pKi 6.7 6.79 6.87 PDSP Ki database
κ OPRK Human Opioid A pKi 6.3 7.31 7.96 PDSP Ki database
κ OPRK Guinea pig Opioid A pKi 7.42 7.42 7.42 PDSP Ki database
μ OPRM Mouse Opioid A pKi 8.17 8.34 8.51 PDSP Ki database
D1 DRD1 Bovine Dopamine A pKi 4.0 4.0 4.0 PDSP Ki database
μ OPRM Bovine Opioid A pKi 7.09 7.29 7.48 PDSP Ki database
δ F1N083 Bovine Opioid A pKi 6.53 6.63 6.73 PDSP Ki database
δ OPRD Mouse Opioid A pKi 6.59 6.59 6.59 PDSP Ki database
μ OPRM Rat Opioid A pKi 4.45 7.08 8.25 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 4.0 4.0 4.0 PDSP Ki database
δ OPRD Rat Opioid A pKi 4.0 5.22 6.44 PDSP Ki database
κ OPRK Rat Opioid A pKi 4.05 6.62 8.3 PDSP Ki database
A1 AA1R Guinea pig Adenosine A pKi 4.0 4.0 4.0 PDSP Ki database
μ OPRM Crab-eating macaque Opioid A pKi 7.82 7.82 7.82 PDSP Ki database
μ OPRM Human Opioid A pKi 7.06 7.06 7.06 Drug Central
A3 AA3R Human Adenosine A pIC50 7.06 7.06 7.06 Drug Central
κ OPRK Human Opioid A pKi 7.07 7.07 7.07 Drug Central
δ OPRD Human Opioid A pKi 7.14 7.14 7.14 Drug Central
μ OPRM Rat Opioid A pKd 7.03 7.03 7.03 Drug Central
μ OPRM Mouse Opioid A pKi 7.05 7.05 7.05 Drug Central
δ OPRD Mouse Opioid A pKd 7.14 7.14 7.14 Drug Central
δ OPRD Rat Opioid A pKd 7.11 7.11 7.11 Drug Central
κ OPRK Guinea pig Opioid A pKi 7.07 7.07 7.07 Drug Central
κ OPRK Rat Opioid A pKd 7.05 7.05 7.05 Drug Central
κ OPRK Mouse Opioid A pIC50 7.08 7.08 7.08 Drug Central
μ OPRM Bovine Opioid A pIC50 7.08 7.08 7.08 Drug Central
CCR5 CCR5 Mouse Chemokine A pKd 7.1 7.1 7.1 Drug Central