cyclosporin A [2658]



cyclosporin A


SMILES C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H](CC)C(=O)N(C)CC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C
InChIKey PMATZTZNYRCHOR-CGLBZJNRSA-N
Sequence XXXLVLAALLV
HELM PEPTIDE1{[meL].[meV].[X1670].[Abu].[Sar].[meL].V.[meL].A.[dA].[meL]}$PEPTIDE1,PEPTIDE1,11:R2-1:R1$$$

Chemical Properties

Hydrogen bond acceptors 12
Hydrogen bond donors 5
Rotatable bonds 15
Log P 3.269
Molecular weight (Da) 1201.8
Stereochemistry info partial

Database connections

Model (AF2) 5-HT2A NK2 FPR1
GPCRdb related ligands

Bioactivities

Receptor Activity Source
Protein Gene Species Family Class Type Min Avg Max Database
Receptor Activity Source
Protein Gene Species Family Class Type Min Avg Max Database

cyclosporin A


Drug properties

Molecular type Peptide
Physiological/Surrogate Surrogate
Approved drug Yes

Distribution across phases (no. indications)

Phase I 0
Phase II 0
Phase III 0
Phase IV 0

Database connections

Model (AF2) 5-HT2A NK2 FPR1
GPCRdb related ligands

Compound is not listed as a drug.