Noradrenaline


SMILES NCC(c1ccc(c(c1)O)O)O
InChIKey SFLSHLFXELFNJZ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 4
Rotatable bonds 2
Molecular weight (Da) 169.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Endogenous
Approved drug No

Database connections

Ligand site mutations β1 β2

Bioactivity

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
β1 ADRB1 Human Adrenoceptors A pKi 6.0 6.0 6.0 Guide to Pharmacology
β2 ADRB2 Human Adrenoceptors A pKi 5.4 5.4 5.4 Guide to Pharmacology
D1 DRD1 Human Dopamine A pKi 4.3 4.3 4.3 Guide to Pharmacology
D5 DRD5 Human Dopamine A pKi 4.9 4.9 4.9 Guide to Pharmacology
D1 DRD1 Human Dopamine A pKi 4.0 4.0 4.0 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 4.0 4.0 4.0 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 4.0 4.0 4.0 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 4.0 4.0 4.0 PDSP Ki database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 4.0 4.0 4.0 PDSP Ki database
5-HT2A 5HT2A Bovine 5-Hydroxytryptamine A pKi 4.0 4.0 4.0 PDSP Ki database
5-HT5A 5HT5A Rat 5-Hydroxytryptamine A pKi 4.0 4.5 5.0 PDSP Ki database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 4.0 4.0 4.0 PDSP Ki database
α1B ADA1B Mouse Adrenoceptors A pKi 5.04 5.04 5.04 PDSP Ki database
α1A ADA1A Rat Adrenoceptors A pKi 6.0 6.0 6.0 PDSP Ki database
α1B ADA1B Rat Adrenoceptors A pKi 4.0 4.0 4.0 PDSP Ki database
5-HT5A 5HT5A Mouse 5-Hydroxytryptamine A pKi 4.0 4.0 4.0 PDSP Ki database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 4.0 4.0 4.0 PDSP Ki database
5-HT6 5HT6R Mouse 5-Hydroxytryptamine A pKi 4.0 4.0 4.0 PDSP Ki database
α2A ADA2A Pig Adrenoceptors A pKi 4.25 4.84 5.43 PDSP Ki database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 4.0 4.0 4.0 PDSP Ki database
β2 ADRB2 Human Adrenoceptors A pKi 4.0 4.12 4.5 PDSP Ki database
D1 DRD1 Rat Dopamine A pKi 4.0 4.0 4.0 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 4.0 4.0 4.0 PDSP Ki database
β2 ADRB2 Greater long-tailed hamster Adrenoceptors A pKi 4.0 4.55 5.1 PDSP Ki database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 5.0 5.09 5.26 PDSP Ki database
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 4.0 4.42 5.26 PDSP Ki database
D5 DRD5 Human Dopamine A pKi 4.0 4.0 4.0 PDSP Ki database
α2A ADA2A Human Adrenoceptors A pKi 4.7 5.03 5.4 PDSP Ki database
TA1 TAAR1 Human Trace amine A pKi 4.0 4.0 4.0 PDSP Ki database
α1A F6PTQ1 Pig Adrenoceptors A pKi 4.0 4.12 4.3 PDSP Ki database
α1B F1RR36 Pig Adrenoceptors A pKi 4.6 4.6 4.6 PDSP Ki database
α1B ADA1B Human Adrenoceptors A pKi 4.0 4.06 4.12 PDSP Ki database
α1A ADA1A Human Adrenoceptors A pKi 4.06 4.06 4.06 PDSP Ki database
α1D ADA1D Human Adrenoceptors A pKi 4.0 4.0 4.0 PDSP Ki database
D2 DRD2 Bovine Dopamine A pKi 4.0 4.12 4.25 PDSP Ki database
D1 DRD1 Bovine Dopamine A pKi 5.09 5.39 5.7 PDSP Ki database
α2B ADA2B Human Adrenoceptors A pKi 4.56 5.02 5.48 PDSP Ki database
α2C ADA2C Human Adrenoceptors A pKi 4.87 5.05 5.23 PDSP Ki database
D2 DRD2 Dog Dopamine A pKi 4.22 4.22 4.22 PDSP Ki database
β1 ADRB1 Human Adrenoceptors A pKi 4.45 4.45 4.45 PDSP Ki database
β3 ADRB3 Human Adrenoceptors A pKi 4.37 4.37 4.37 PDSP Ki database
α2A ADA2A Mouse Adrenoceptors A pKi 4.85 4.85 4.85 PDSP Ki database